Pulmonary hypertension in Nigerian adults with sickle cell anemia
| Autor: | N. O. Akinola, Anthony O Akintomide, RA Adebayo, Valentine N. Amadi, Michael O Balogun |
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| Rok vydání: | 2017 |
| Předmět: |
Male
Endocrinology Diabetes and Metabolism 030204 cardiovascular system & hematology Doppler echocardiography Hospitals University 0302 clinical medicine pulmonary hypertension Prevalence Pharmacology (medical) Young adult Original Research Exercise Tolerance Tricuspid valve medicine.diagnostic_test Hematology General Medicine Echocardiography Doppler Tricuspid Valve Insufficiency Sickle cell anemia medicine.anatomical_structure Hemoglobinopathy Cardiology Female Tricuspid Valve Cardiology and Cardiovascular Medicine Adult medicine.medical_specialty Adolescent Hypertension Pulmonary Nigeria Nigerian adults Walk Test Anemia Sickle Cell doppler-derived Pulmonary Artery Young Adult 03 medical and health sciences sickle cell anemia medicine.artery Internal medicine medicine Humans Arterial Pressure business.industry Public Health Environmental and Occupational Health medicine.disease Pulmonary hypertension Vascular Health and Risk Management Blood pressure 030228 respiratory system Pulmonary artery business |
| Zdroj: | Vascular Health and Risk Management |
| ISSN: | 1178-2048 |
| Popis: | Valentine N Amadi,1 Michael O Balogun,2 Norah O Akinola,3 Rasaaq A Adebayo,2 Anthony O Akintomide2 1Department of Internal Medicine, Federal Medical Centre, Asaba, Delta State, 2Cardiac Care Unit, Department of Medicine, 3Department of Haematology and Blood Transfusion, Obafemi Awolowo University Teaching Hospitals Complex, Ile-Ife, Osun State, Nigeria Background: Sickle cell anemia (SCA) is the commonest hemoglobinopathy and is associated with high morbidity and mortality. Pulmonary hypertension (PH) is reported to play a significant role in this regard. There is very limited literature on PH in SCA in Nigeria.Objectives: The objectives of this study were to determine the prevalence of Doppler-derived PH in SCA, assess its influence on exercise capacity, and determine the correlates and predictors of measures of estimated pulmonary pressure.Methods: A total of 92 SCA subjects had echocardiography and 6-minute self-paced walking exercise. PH was diagnosed by Doppler echocardiography on finding a tricuspid regurgitant velocity (TRV) of ≥2.5m/s. The pulmonary flow profile was also assessed to estimate mean pulmonary arterial pressure (MPAP).Results: Doppler-derived PH was detected in 23.9% of adults with SCA. The 6-minute walking distance (6MWD) was significantly lower in SCA adults with PH than in those without PH (380.33 ± 63.17m vs 474.28 ± 76.74m; p = 0.014). TRV and estimated MPAP had a significant inverse correlation with the 6MWD (r = -0.442; p < 0.001 and r = -0.571; p < 0.001, respectively).Conclusion: PH as derived by Doppler is common in Nigerian adults with SCA and has a significantly negative influence on exercise capacity. Screening for PH should be encouraged to optimize management and thus improve their quality of life and life expectancy. Keywords: pulmonary hypertension, Nigerian adults, sickle cell anemia, doppler-derived |
| Databáze: | OpenAIRE |
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