Intratumoral Production of IL-6 in B Cell Chronic Lymphocytic Leukemia and B Lymphomas
| Autor: | O Devergne, Marie-Claude Crevon, Michel Peuchmaur, M B Leger-Ravet, Dominique Emilie, Martine Raphael, Pierre Galanaud, Jean Coumbaras |
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| Rok vydání: | 1993 |
| Předmět: |
CD20
Cancer Research Lymphoma B-Cell Interleukin-6 Growth factor medicine.medical_treatment Chronic lymphocytic leukemia Gene Expression Receptors Interleukin Hematology In situ hybridization Biology medicine.disease Leukemia Lymphocytic Chronic B-Cell Receptors Interleukin-6 Paracrine signalling Cytokine Oncology Immunology biology.protein Cancer research medicine Humans Interleukin 6 Clone (B-cell biology) |
| Zdroj: | Leukemia & Lymphoma. 11:411-417 |
| ISSN: | 1029-2403 1042-8194 |
| DOI: | 10.3109/10428199309067934 |
| Popis: | Interleukin-6 is a major B lymphocyte growth factor, and may play a role in the proliferation of malignant B lymphocytes. In order to provide arguments supporting such a role, the intratumoral production of IL-6 was studied by in situ hybridization and immunohistochemistry in 53 neoplastic tissues from B cell chronic lymphocytic leukemia or B lymphomas. IL-6-producing cells were detected in all samples but 5. However, the number of IL-6 producing cells was variable amongst the different cases. Increased density of IL-6-producing cells was highly dependent on the presence of malignant immunoblasts within the neoplastic clone. IL-6 was produced in a paracrine way, macrophages and endothelial cells being the main producers of the cytokine while malignant immunoblasts expressed the IL-6 receptor. Taken together, these results suggest that IL-6 may indeed act as a growth factor for malignant cells in some B lymphoproliferations and that this paracrine loop could be the target of new therapeutic approaches. |
| Databáze: | OpenAIRE |
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