Novel Paju Apodemus paramyxovirus 1 and 2, harbored by Apodemus agrarius in the Republic of Korea

Autor: Chang-Sub Uhm, Seung Hye Cho, Jin Won Song, Seunghee Cho, Kyungmin Park, Jin Sun No, Heung-Chul Kim, Terry A. Klein, Jong Woo Kim, Bong Hyun Kim, Jingyeong Lee, Won-Keun Kim, Seungchan Cho, Kijin Kim, Shailesh Budhathoki, Geum-Young Lee, Seungho Lee
Rok vydání: 2021
Předmět:
Zdroj: Virology. 562:40-49
ISSN: 0042-6822
DOI: 10.1016/j.virol.2021.06.011
Popis: Paramyxoviruses harbored by multiple natural reservoirs pose a potential threat to public health. Jeilongvirus has been proposed as a novel paramyxovirus genus found in rodents, bats, and cats. Paramyxovirus RNA was detected in 108/824 (13.1%) Apodemus agrarius captured at 14 trapping sites in the Republic of Korea. We first present two genetically distinct novel paramyxoviruses, Paju Apodemus paramyxovirus 1 (PAPV-1) and 2 (PAPV-2). The disparity between PAPV-1 (19,716 nucleotides) and -2 (17,475 nucleotides) revealed the presence of the SH gene and length of the G gene in the genome organization. The phylogeny of PAPV-1 and -2 belonged to distinct genetic lineages of Jeilongvirus, respectively, even though these viruses were originated from A. agrarius. PAPV-1 infected human epithelial and endothelial cells, facilitating the induction of type I/III interferons, interferon-stimulated genes, and pro-inflammatory cytokines. Therefore, this study provides insights into the molecular epidemiology, genetic diversity, and virus-host interactions of novel rodent-borne paramyxoviruses.
Databáze: OpenAIRE
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