Hemorrhoids detected at colonoscopy: an infrequent cause of false-positive fecal immunochemical test results
| Autor: | Chris J. J. Mulder, Jochim S. Terhaar sive Droste, Leo G. van Rossum, René W M van der Hulst, Annekatrien C.T.M. Depla, A. A. Bouman, Frank A. Oort, Pieter Scholten, Veerle M.H. Coupé, Ruud J. Loffeld, Sietze T. van Turenhout, Gerrit A. Meijer |
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| Přispěvatelé: | Gastroenterology and hepatology, Epidemiology and Data Science, Pathology, Clinical chemistry, CCA - Oncogenesis |
| Rok vydání: | 2011 |
| Předmět: |
Adenoma
Male medicine.medical_specialty Colorectal cancer Colonoscopy Logistic regression Gastroenterology Hemorrhoids Internal medicine Medicine Humans Radiology Nuclear Medicine and imaging False Positive Reactions Prospective cohort study Early Detection of Cancer Aged Anus Diseases medicine.diagnostic_test business.industry Odds ratio Middle Aged medicine.disease Logistic Models Fecal Immunochemical Test Evaluation of complex medical interventions [NCEBP 2] Occult Blood Female Abnormality business Colorectal Neoplasms Gastrointestinal Hemorrhage |
| Zdroj: | Gastrointestinal Endoscopy, 76, 136-43 van Turenhout, S T, Oort, F A, Terhaar sive Droste, J S, Coupé, V M H, van der Hulst, R W, Loffeld, R J, Scholten, P, Depla, A C T M, Bouman, A A, Meijer, G A, Mulder, C J J & van Rossum, L G M 2012, ' Hemorrhoids detected at colonoscopy: an infrequent cause of false-positive fecal immunochemical test results ', Gastrointestinal Endoscopy, vol. 76, no. 1, pp. 136-143 . https://doi.org/10.1016/j.gie.2012.03.169 Gastrointestinal Endoscopy, 76, 1, pp. 136-43 Gastrointestinal Endoscopy, 76(1), 136-143. Mosby Inc. |
| ISSN: | 1097-6779 0016-5107 |
| DOI: | 10.1016/j.gie.2012.03.169 |
| Popis: | Item does not contain fulltext BACKGROUND: Colorectal cancer screening by fecal immunochemical tests (FITs) is hampered by frequent false-positive (FP) results and thereby the risk of complications and strain on colonoscopy capacity. Hemorrhoids might be a plausible cause of FP results. OBJECTIVE: To determine the contribution of hemorrhoids to the frequency of FP FIT results. DESIGN: Retrospective analysis from prospective cohort study. SETTING: Five large teaching hospitals, including 1 academic hospital. PATIENTS: All subjects scheduled for elective colonoscopy. INTERVENTIONS: FIT before bowel preparation. MAIN OUTCOME MEASUREMENTS: Frequency of FP FIT results in subjects with hemorrhoids as the only relevant abnormality compared with FP FIT results in subjects with no relevant abnormalities. Logistic regression analysis to determine colonic abnormalities influencing FP results. RESULTS: In 2855 patients, 434 had positive FIT results: 213 had advanced neoplasia and 221 had FP results. In 9 individuals (4.1%; 95% CI, 1.4-6.8) with an FP FIT result, hemorrhoids were the only abnormality. In univariate unadjusted analysis, subjects with hemorrhoids as the only abnormality did not have more positive results (9/134; 6.7%) compared with subjects without any abnormalities (43/886; 4.9%; P = .396). Logistic regression identified hemorrhoids, nonadvanced polyps, and a group of miscellaneous abnormalities, all significantly influencing false positivity. Of 1000 subjects with hemorrhoids, 67 would have FP results, of whom 18 would have FP results because of hemorrhoids only. LIMITATIONS: Potential underreporting of hemorrhoids; high-risk individuals. CONCLUSIONS: Hemorrhoids in individuals participating in colorectal cancer screening will probably not lead to a substantial number of false-positive test results. 01 juli 2012 |
| Databáze: | OpenAIRE |
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