A Patient with HCV Infection and a Sustained Virological Response to Direct-acting Antiviral Treatment Who Developed Inclusion Body Myositis

Autor: Satoshi Saitoh, Hitomi Sezaki, Shunichiro Fujiyama, Kenji Ikeda, Yoshiyuki Suzuki, Masahiro Kobayashi, Hiromitsu Kumada, Mariko Kobayashi, Fumitaka Suzuki, Toru Kuwano, Yusuke Kawamura, Norio Akuta, Tetsuya Hosaka, Yasuji Arase
Rok vydání: 2018
Předmět:
hepatitis C virus
Cyclopropanes
mixed cryoglobulinemia
medicine.medical_specialty
Macrocyclic Compounds
Proline
Sustained Virologic Response
Lactams
Macrocyclic
Hepatitis C virus
education
Case Report
medicine.disease_cause
Antiviral Agents
Gastroenterology
Myositis
Inclusion Body
Virological response
03 medical and health sciences
0302 clinical medicine
Internal medicine
Internal Medicine
medicine
Humans
Anilides
Aged
direct-acting antiviral
Sulfonamides
Ritonavir
Muscle biopsy
medicine.diagnostic_test
business.industry
Muscle weakness
inclusion body myositis
Valine
General Medicine
Hepatitis C
Chronic
medicine.disease
Dysphagia
Cryoglobulinemia
Mixed cryoglobulinemia
Female
030211 gastroenterology & hepatology
Carbamates
sustained virological response
medicine.symptom
Inclusion body myositis
business
030217 neurology & neurosurgery
Direct acting
Zdroj: Internal Medicine
ISSN: 1349-7235
0918-2918
DOI: 10.2169/internalmedicine.0585-17
Popis: We report the case of a 75-year-old woman who was found to have hepatitis C virus (HCV) infection in 1987. Before treatment in 2016, she was found to have mixed cryoglobulinemia (MC). Direct-acting antiviral (DAA) treatment produced a sustained virological response 12 (SVR12). She noticed gradual muscle weakness in 2015 and the gradual development of dysarthria and dysphagia in 2017. We performed a muscle biopsy that showed inclusion body myositis (IBM). To the best of our knowledge, this is first case of a patient with HCV infection, MC, and IBM, in which MC and IBM did not improve after an SVR12 was obtained by DAA treatment.
Databáze: OpenAIRE
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