Epidemiology of haemophagocytic lymphohistiocytosis at the population level in Germany

Autor:	David Kuron, Jakob Christoph Voran, Friedrich Alexander von Samson‐Himmelstjerna, Claudia Baldus, Ulrich Kunzendorf, Kevin Schulte, Benedikt Kolbrink
Rok vydání:	2022
Předmět:	Hematology
Zdroj:	British journal of haematologyREFERENCES.
ISSN:	1365-2141
Popis:	We retrospectively analysed all German inpatient cases of haemophagocytic lymphohistiocytosis (HLH) from 2014 to 2020 to describe the epidemiology, clinical course, and underlying diseases of 4065 HLH patients. The age-standardized incidence rate of HLH in Germany was 0.52/100 000 people in 2014 and steadily increased by 10% per year to 0.97/100 000 in 2020 (mean 0.70/100 000). Inpatient deaths related to HLH increased from 0.84/1 000 000 people in 2014 to 2.32/1 000 000 people in 2020, caused by rising numbers of older HLH patients. Overall, HLH is more frequent than previously expected and incidence as well as HLH-related deaths increased significantly.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b65a61810fc8f000a713b907e448f717 https://pubmed.ncbi.nlm.nih.gov/36535304 Zobrazit plný text záznamu Plný text