Comparative Effectiveness Research of Disease-Modifying Therapies for the Management of Multiple Sclerosis: Analysis of a Large Health Insurance Claims Database
| Autor: | Ming-Yi Huang, Monica Fay, Ning Wu, Michael R. Edwards, Andrew Lee, Jacqueline Nicholas, Wei-Shi Yeh, Aaron Boster |
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| Rok vydání: | 2017 |
| Předmět: |
Oncology
medicine.medical_specialty Comparative effectiveness research Rate ratio Dimethyl fumarate Multiple sclerosis 03 medical and health sciences chemistry.chemical_compound Glatiramer acetate 0302 clinical medicine Internal medicine Teriflunomide medicine Disease-modifying therapy 030212 general & internal medicine Original Research business.industry Fingolimod Interferon beta Management of multiple sclerosis medicine.disease Comparative effectiveness Neurology chemistry Physical therapy Neurology (clinical) business 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Neurology and Therapy |
| ISSN: | 2193-6536 2193-8253 |
| DOI: | 10.1007/s40120-017-0064-x |
| Popis: | Introduction Limited data are available on the real-world effectiveness of newer oral disease-modifying therapies (DMTs) in multiple sclerosis. The purpose of this study was to retrospectively compare the real-world effectiveness of dimethyl fumarate (DMF), fingolimod, teriflunomide, and injectable DMTs in routine clinical practice based on US claims data. Methods Patients newly-initiating DMF, interferon beta (IFNβ), glatiramer acetate (GA), teriflunomide, or fingolimod in 2013 were identified in the Truven MarketScan Commercial Claims Databases (N = 6372). Relapse episodes were identified based on a published claim-based algorithm and used to determine the annualized relapse rate (ARR) for the year before and after initiating therapy. Poisson and negative binomial regression was used to determine the adjusted incidence rate ratio (IRR) for each therapy relative to DMF. Results Significant ARR reductions in the year after initiating therapy were reported for DMF and fingolimod (P |
| Databáze: | OpenAIRE |
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