Increase of serum estradiol in cirrhotic men treated by transjugular intrahepatic portosystemic stent shunt
| Autor: | Christian G. Schindler, Giuliano Ramadori, Wolfgang Wuttke, W Nolte, Hans R. Figulla, Heinz Hartmann, Michael Hüfner |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Adult
Liver Cirrhosis Male medicine.medical_specialty Cirrhosis medicine.medical_treatment Hyperestrogenism Gastroenterology 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Sex hormone-binding globulin Dehydroepiandrosterone sulfate Erectile Dysfunction Sex Hormone-Binding Globulin Internal medicine Humans Medicine Prospective Studies Gonadal Steroid Hormones Aged Estradiol Hepatology biology business.industry Androstenedione Middle Aged medicine.disease Erectile dysfunction Endocrinology chemistry Sex steroid 030220 oncology & carcinogenesis biology.protein Female 030211 gastroenterology & hepatology Portasystemic Shunt Transjugular Intrahepatic medicine.symptom business Luteinizing hormone Transjugular intrahepatic portosystemic shunt |
| Zdroj: | Journal of Hepatology. 34:818-824 |
| ISSN: | 0168-8278 |
| Popis: | Background/Aims : Liver cirrhosis is frequently associated with sexual dysfunction and hormonal abnormalities. To evaluate the effect of portosystemic shunting on sex steroid serum concentrations, a prospective study was performed in cirrhotic patients treated consecutively and electively by transjugular intrahepatic portosystemic stent shunt (TIPS). Methods : In 27 patients with liver cirrhosis we measured serum levels of testosterone (T), sexual hormone binding globulin (SHBG), luteinizing hormone, follicle-stimulating hormone, dehydroepiandrosterone sulfate, androstenedione (A), estradiol (E 2 ), 17-OH-progesterone and the T/SHBG ratio before and 3 months after TIPS. Results : In men (n=17) 3 months after TIPS, A and E 2 significantly increased, with mean serum levels rising from 4.4±2.5 to 5.6±2.9 ng/ml (P=0.04) and from 27±9 to 40±19 pg/ml (P=0.003), respectively. In contrast to A the increase of E 2 persisted at 9 and 15 months after TIPS. Erectile dysfunction increased from 30% before TIPS to 70% after TIPS. In women (n=10) A and E 2 levels did not change significantly after TIPS. Conclusions : TIPS aggravated hormonal dysbalance of sex steroids in favor of estrogens (hyperestrogenism) in men. |
| Databáze: | OpenAIRE |
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