Unstable neurons underlie a stable learned behavior
| Autor: | Carlos Lois, William A. Liberti, Jeffrey E. Markowitz, Darrell N. Kotton, Grigori Guitchounts, Daniel P. Leman, Derek C. Liberti, L. Nathan Perkins, Tarciso A. F. Velho, Timothy J. Gardner |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Male
0301 basic medicine animal structures Premotor cortex Population Action Potentials Article 03 medical and health sciences 0302 clinical medicine Neural Pathways medicine Animals Birdsong education Zebra finch Motor skill Neurons education.field_of_study General Neuroscience Sleep in non-human animals 030104 developmental biology medicine.anatomical_structure nervous system Excitatory postsynaptic potential behavior and behavior mechanisms Finches Vocalization Animal Day to day Sleep Psychology Neuroscience Nucleus 030217 neurology & neurosurgery |
| Zdroj: | Repositório Institucional da UFRN Universidade Federal do Rio Grande do Norte (UFRN) instacron:UFRN Nature neuroscience |
| Popis: | Motor skills can be maintained for decades, but the biological basis of this memory persistence remains largely unknown. The zebra finch, for example, sings a highly stereotyped song that is stable for years, but it is not known whether the precise neural patterns underlying song are stable or shift from day to day. Here, we demonstrate that the population of projection neurons coding for song in the pre-motor nucleus HVC change from day to day. The most dramatic shifts occur over intervals of sleep. In contrast to the transient participation of excitatory neurons, ensemble measurements dominated by inhibition persist unchanged even after damage to downstream motor nerves. These observations offer a principle of motor stability: spatio-temporal patterns of inhibition can maintain a stable scaffold for motor dynamics while the population of principle neurons that directly drive behavior shift from one day to the next. |
| Databáze: | OpenAIRE |
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