Sphingolipid Signaling Pathways as Potential Therapeutic Targets in Gliomas
| Autor: | James R. Van Brocklyn |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Ceramide
Programmed cell death Cell Survival Malignant brain tumor Apoptosis Biology Ceramides chemistry.chemical_compound Cell Movement Sphingosine Cell Line Tumor Glioma Drug Discovery medicine Animals Humans Cell survival Pharmacology Sphingolipids Brain Neoplasms General Medicine medicine.disease Sphingolipid nervous system diseases chemistry Cell culture Cancer research lipids (amino acids peptides and proteins) Lysophospholipids Signal transduction Glioblastoma Signal Transduction |
| Zdroj: | Mini-Reviews in Medicinal Chemistry. 7:984-990 |
| ISSN: | 1389-5575 |
| DOI: | 10.2174/138955707782110123 |
| Popis: | Glioblastoma multiforme (GBM) is a highly malignant brain tumor. The interconvertible bioactive sphingolipids sphingosine-1-phosphate (S1P) and ceramide have profound effects on GBM cells, with ceramide causing cell death and S1P leading to cell survival, proliferation and invasion. This review will examine the effects of ceramide and S1P on glioma cells and the therapeutic potential of these pathways. |
| Databáze: | OpenAIRE |
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