Clinico-microbiological Profile of Burkholderia cepacia Keratitis: a Case Series

Autor: Hsin-Chiung Lin, Ching-Hsi Hsiao, David Hui-Kang Ma, Hung-Chi Chen, Ming-Chih Ho, Eugene Yu-Chuan Kang, Lung-Kun Yeh, Hsin-Yuan Tan
Rok vydání: 2020
Předmět:
Male
Corneal Infection
genetic structures
lcsh:QR1-502
Visual Acuity
Ceftazidime
Drug resistance
Burkholderia cepacia
lcsh:Microbiology
drug susceptibility
0302 clinical medicine
Medical microbiology
Levofloxacin
Drug Resistance
Multiple
Bacterial
Medicine
Aged
80 and over
0303 health sciences
biology
Burkholderia Infections
General Medicine
Middle Aged
corneal ulcer
Infectious Diseases
Female
psychological phenomena and processes
medicine.drug
Microbiology (medical)
Adult
medicine.medical_specialty
behavioral disciplines and activities
Keratitis
lcsh:Infectious and parasitic diseases
03 medical and health sciences
Humans
lcsh:RC109-216
Aged
Retrospective Studies
030306 microbiology
business.industry
Research
lcsh:RM1-950
biology.organism_classification
medicine.disease
Dermatology
Burkholderia
lcsh:Therapeutics. Pharmacology
nervous system
030221 ophthalmology & optometry
business
Zdroj: Annals of Clinical Microbiology and Antimicrobials
Annals of Clinical Microbiology and Antimicrobials, Vol 20, Iss 1, Pp 1-6 (2021)
DOI: 10.21203/rs.3.rs-26844/v1
Popis: Background Burkholderia cepacia, an opportunistic pathogen mainly affecting patients with cystic fibrosis or immunocompromised, has rarely been documented as a cause of corneal infection. The clinical and microbiological profiles of B. cepacia keratitis are reported herein. Methods We retrospectively reviewed the medical record of 17 patients with culture-proven B. cepacia keratitis, treated between 2000 and 2019 at Chang Gung Memorial Hospital, Taiwan. Our data included predisposing factors, clinical presentations, treatments, and visual outcomes of B. cepacia keratitis as well as the drug susceptibility of the causative agent. Results The most common predisposing factor for B. cepacia keratitis was preexisting ocular disease (seven, 41.2%), particularly herpetic keratitis (five). Polymicrobial infection was detected in seven (41.2%) eyes. All B. cepacia isolates were susceptible to ceftazidime. Main medical treatments included levofloxacin or ceftazidime. Surgical treatment was required in five (29.4%) patients. Only four (23.5%) patients exhibited final visual acuity better than 20/200. Conclusions B. cepacia keratitis primarily affects patients with preexisting ocular disease, particularly herpetic keratitis, and responds well to ceftazidime or fluoroquinolones. However, the visual outcomes are generally poor.
Databáze: OpenAIRE
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