Alkylphenol Activity against Candida spp. and Microsporum canis: A Focus on the Antifungal Activity of Thymol, Eugenol and O-Methyl Derivatives
| Autor: | Ynayara C. Lima, Raquel Oliveira dos Santos Fontenelle, Rossana de Aguiar Cordeiro, Raimunda Sâmia Nogueira Brilhante, André Jalles Monteiro, Nilce Viana Gramosa Pompeu de Sousa Brasil, José Júlio Costa Sidrim, Marcos Fábio Gadelha Rocha, Selene Maia de Morais, Erika H.S. Brito |
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| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
Antifungal Agents
Drug Evaluation Preclinical Pharmaceutical Science Microbial Sensitivity Tests Article Analytical Chemistry Microbiology lcsh:QD241-441 estragole chemistry.chemical_compound Minimum inhibitory concentration lcsh:Organic chemistry Phenols Drug Discovery Eugenol dermathophytes Microsporum Microsporum canis Food science Physical and Theoretical Chemistry Thymol Anethole Candida biology Organic Chemistry Broth microdilution biology.organism_classification Griseofulvin methyl-derivatives thymol eugenol chemistry Chemistry (miscellaneous) Molecular Medicine Estragole |
| Zdroj: | Molecules Molecules, Vol 16, Iss 8, Pp 6422-6431 (2011) Molecules; Volume 16; Issue 8; Pages: 6422-6431 |
| ISSN: | 1420-3049 |
| Popis: | In recent years there has been an increasing search for new antifungal compounds due to the side effects of conventional antifungal drugs and fungal resistance. The aims of this study were to test in vitro the activity of thymol, eugenol, estragole and anethole and some O-methyl-derivatives (methylthymol and methyleugenol) against Candida spp. and Microsporum canis. The broth microdilution method was used to determine the minimum inhibitory concentration (MIC). The minimum fungicidal concentrations (MFC) for both Candida spp. and M. canis were found by subculturing each fungal suspension on potato dextrose agar. Thymol, methylthymol, eugenol, methyl-eugenol, anethole, estragole and griseofulvin respectively, presented the following MIC values against M. canis: 4.8–9.7; 78–150; 39; 78–150; 78–150; 19–39 µg/mL and 0.006–2.5 mg/mL. The MFC values for all compounds ranged from 9.7 to 31 µg/mL. Concerning Candida spp, thymol, methylthymol, eugenol, methyleugenol, anethole, estragole and amphotericin, respectively, showed the following MIC values: 39; 620–1250; 150–620; 310–620; 620; 620–1250 and 0.25–2.0 mg/mL. The MFC values varied from 78 to 2500 µg/mL. All tested compounds thus showed in vitro antifungal activity against Candida spp. and M. canis. Therefore, further studies should be carried out to confirm the usefulness of these alkylphenols in vivo. |
| Databáze: | OpenAIRE |
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