Anti-pancreatic-cancer effect of a newly bred cabbage line, Amtak-ssamchae, is mediated by a reduction in regulatory-T-cell recruitment
| Autor: | Soo Jeong Kim, Sunggun Kim, Na Yeon Kim, Kwang Woo Hwang, Kicheol Gil, Eun-sang Jo, Dongbok Park, So-Young Park, Ji Sung Park |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Chemokine receptor ligand Regulatory T cell Chemokine receptor Cell Population Medicine (miscellaneous) Spleen Biology 03 medical and health sciences 0404 agricultural biotechnology In vivo Pancreatic cancer β-carotene medicine TX341-641 education education.field_of_study 030109 nutrition & dietetics Nutrition and Dietetics Nutrition. Foods and food supply 04 agricultural and veterinary sciences medicine.disease 040401 food science Amtak-ssamchae In vitro medicine.anatomical_structure Mechanism of action Cancer research medicine.symptom Food Science |
| Zdroj: | Journal of Functional Foods, Vol 58, Iss, Pp 301-310 (2019) |
| ISSN: | 1756-4646 |
| Popis: | We aimed to investigate possible anticancer effects of Amtak-ssamchae (a newly bred cabbage line containing more carotenoids) in an in vitro pancreatic-tumor cell model and an in vivo model (Panc02 cells). In an in vitro assay, Amtak-ssamchae significantly reduced the viability of Panc02 cells relative to normal ssamchae. Furthermore, an Amtak-ssamchae extract significantly reduced the tumor size in mice inoculated with Panc02 cells, and this effect was accompanied by changes in the cell population in/near the tumor and spleen. Treatment with the extract of the new cabbage line blocked regulatory-T-cell recruitment, which is known as the main pathological mechanism of action of pancreatic cancer to avoid host immunity. Additionally, Amtak-ssamchae (not the normal line) contained β-carotene (at 27.9 ± 2.1 μg/g). Thus, we suggest that the Amtak-ssamchae extract could be a resource for natural supplements and functional foods for combating pancreatic cancer. |
| Databáze: | OpenAIRE |
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