Quantitative biochemical analysis of samples from squamous cell carcinoma
| Autor: | Ross Cd, Medina Je |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
0301 basic medicine
Cell Biology Malate dehydrogenase 03 medical and health sciences chemistry.chemical_compound Stroma Malate Dehydrogenase Lactate dehydrogenase medicine Humans chemistry.chemical_classification Mixed tumor L-Lactate Dehydrogenase 030102 biochemistry & molecular biology Metabolism medicine.disease Molecular biology 030104 developmental biology Enzyme medicine.anatomical_structure Otorhinolaryngology Biochemistry chemistry Carcinoma Squamous Cell Surgery Energy Metabolism Anaerobic exercise |
| Zdroj: | Otolaryngology–Head and Neck Surgery. 119:455-459 |
| ISSN: | 1097-6817 0194-5998 |
| Popis: | Samples of tumor, tumor stroma, and mixed tumor and stroma were microdissected from three squamous cell carcinomas, as well as from adjacent nontumor tissue and assayed for malate dehydrogenase or lactate dehydrogenase activity as indicators of the relative contribution of aerobic and anaerobic processes, respectively, to energy metabolism. Malate and lactate dehydrogenase activities were greater in tumor tissue than in tumor stroma in all three tumors. However, the magnitudes of malate and lactate dehydrogenase activities were different among the tumors, suggesting that tumors vary in the degree to which aerobic and anaerobic reactions contribute to energy production. These results indicate that a quantitative assessment of enzymes involved in energy production may be a useful probe in the understanding of tumor metabolism. |
| Databáze: | OpenAIRE |
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