Determinants of the Severity of Exercise‐Induced Bronchoconstriction in Patients with Asthma
| Autor: | Kenichiro Otani, Shigeo Fujimoto, Junichi Yoshikawa, Hiroshi Kanazawa, Kazuto Hirata, Hiroshi Fujiwara |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Adult
Male Pulmonary and Respiratory Medicine medicine.medical_specialty Provocation test Bronchi Severity of Illness Index Gastroenterology Pulmonary function testing Capillary Permeability Risk Factors Internal medicine Severity of illness medicine Humans Immunology and Allergy Asthma business.industry medicine.disease Respiratory Function Tests respiratory tract diseases Asthma Exercise-Induced Eosinophils Anesthesia Pediatrics Perinatology and Child Health Sputum Female Bronchoconstriction Methacholine medicine.symptom Airway business human activities medicine.drug |
| Zdroj: | Journal of Asthma. 41:271-278 |
| ISSN: | 1532-4303 0277-0903 |
| Popis: | In examining the mechanisms of exercise-induced bronchoconstriction (EIB), it is important to determine which factors most strongly affect the severity of EIB. We determined such factors in patients with asthma by stepwise multiple-regression analysis.Twenty-three patients with asthma underwent pulmonary function tests, methacholine provocation test, and sputum induction. Eosinophilic inflammatory indices and airway vascular permeability index (ratio of albumin concentrations in induced sputum and serum) were examined in sputum samples, and then an exercise test was performed by all asthmatics.There was a significant correlation between the severity of EIB and degree of eosinophilic inflammation in induced sputum. Moreover, there was a significant correlation between the severity of EIB and airway vascular permeability index. Although we could not find a significant correlation between the severity of EIB and 1-sec forced expired volume, 20% provocation concentration of (PC20) methacholine tended to be correlated with the severity of EIB. By stepwise multiple-regression analysis, we also found that airway vascular permeability index, eosinophil cationic protein levels in sputum, and PC20 methacholine are independent predictors of the severity of EIB.We found that airway vascular hyperpermeability, eosinophilic inflammation, and bronchial hyperreactivity are independent factors predicting the severity of EIB. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|