Severe, Persistent and Fatal Delirium in Psychogeriatric Patients Admitted to a Psychiatric Hospital
| Autor: | Letty Oudewortel, Paulien M. Brandt, Ingrid S. Jans, Willem A. van Gool |
|---|---|
| Přispěvatelé: | Neurology |
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
medicine.medical_specialty
Pediatrics Hallucinations Cognitive Neuroscience Dementia with Lewy bodies Alzheimerߣs disease Neuropathology lcsh:Geriatrics behavioral disciplines and activities Delusions lcsh:RC346-429 Progressive supranuclear palsy mental disorders Medicine Psychiatric hospital Dementia Original Research Article Cognitive decline Psychiatry lcsh:Neurology. Diseases of the nervous system business.industry Medical record Alzheimer's disease medicine.disease nervous system diseases Treatment Psychiatry and Mental health Severe delirium lcsh:RC952-954.6 Persistent delirium Delirium medicine.symptom business |
| Zdroj: | Dementia and geriatric cognitive disorders extra, 5(2), 253-264. S. Karger AG Dementia and Geriatric Cognitive Disorders Extra, Vol 5, Iss 2, Pp 253-264 (2015) Dementia and Geriatric Cognitive Disorders EXTRA |
| ISSN: | 1664-5464 |
| Popis: | Background/Aims: Although delirium is generally regarded as a transient syndrome, persistence of delirium in patients with cognitive impairment - even with fatal outcome - has been reported as well. This study aims to describe the clinical features and neuropathological correlates of this type of delirium. Methods: Inclusion criteria for this case series were: (1) severe persistent delirium until death, (2) history of cognitive decline and (3) consent for brain autopsy. Medical records were examined in combination with collected clinical data and neuropathological findings. Result: In 15 patients, all living at home before admission, episodes with delirium lasted for 4.2 months on average. No distinct medical causes of persistent delirium could be identified. Pathological diagnoses included Alzheimer's disease and dementia with Lewy bodies as well as single cases of Creutzfeldt-Jakob disease and progressive supranuclear palsy. Conclusion: Severe, persistent and fatal delirium in patients with cognitive impairment can occur relatively early in the disease trajectory and is associated with diverse neuropathologies. |
| Databáze: | OpenAIRE |
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