Anthraquinones in Rheum palmatum and Rumex dentatus(Polygonaceae), and phorbol esters in Jatropha curcas(Euphorbiaceae) with molluscicidal activity against the schistosome vector snails Oncomelania,Biomphalaria, and Bulinus
| Autor: | Michael Wink, Yong-Long Li, Frank Sporer, Andreas Ruppel, J. Jourdane, S. Y. Liu, R. Henning |
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| Rok vydání: | 1997 |
| Předmět: |
Molluscacides
Bulinus Snails Jatropha Biomphalaria Anthraquinones Bulinus globosus Disease Vectors Phorbol Esters parasitic diseases Botany Animals Humans Schistosomiasis Biomphalaria glabrata Rheum Chromatography High Pressure Liquid Plants Medicinal biology fungi Public Health Environmental and Occupational Health biology.organism_classification Infectious Diseases Molluscicide Oncomelania hupensis Parasitology Rumex dentatus |
| Zdroj: | Tropical Medicine and International Health. 2:179-188 |
| ISSN: | 1365-3156 1360-2276 |
| DOI: | 10.1046/j.1365-3156.1997.d01-242.x |
| Popis: | Hot water extracts of Rheum plamatum and Rheum dentatus (from China) showed molluscicidal activity against the snails Oncomelania hupensis, Biomphalaria glabrata and Bulinus globosus, which are vectors of Schistosoma japonicum, S. mansoni and S. haematobium, respectively. Activity was correlated with antraquinones which were identified by HPLC: rhein and chrysophanol-anthron were most active (> 50% dead snails after 2 days in a 0.03% solution). Molluscicidal activity was intermediate with Rheum-emodin and physcion and was not detectable with cinnamic acid or Aloe-emodin. The snail O. hupensis tended to be more sensitive for several compounds than B. glabrata. Extracts of Jatropha curcas seeds (from Mali) showed molluscicidal activity against both B. glabrata and O. hupensis, the latter being the more sensitive snail. The activity was associated with phorbol esters extracted from Jatropha oil. Of the pure phorbol esters tested, 4 beta-phorbol-13-decanoate killed both snail species at a concentration of 0.001% (10 p.p.m). As Jatropha is locally grown in Mali for other purposes, it might potentially be exploited for schistosomiasis control. |
| Databáze: | OpenAIRE |
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