Atypical retinal pigment epithelial defects with retained photoreceptor layers: a so far disregarded finding in age related macular degeneration
| Autor: | Marion R. Munk, Eduardo Cunha-Souza, Vittorio Capuano, Giuseppe Querques, Inger Christine Munch, Sarah Mrejen, Xuejing Chen, Murilo Wendeborn Rodrigues, Martin S. Zinkernagel, David Sarraf, Andreas Ebneter, Helena Giannakaki-Zimmermann, Daraius Shroff, Charu Gupta |
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| Přispěvatelé: | Giannakaki-Zimmermann, H., Querques, G., Munch, I. C., Shroff, D., Sarraf, D., Chen, X., Cunha-Souza, E., Mrejen, S., Capuano, V., Rodrigues, M. W., Gupta, C., Ebneter, A., Zinkernagel, M. S., Munk, M. R. |
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Male
Visual acuity genetic structures Visual Acuity Retinal Pigment Epithelium/pathology Retinal Pigment Epithelium Fundus (eye) Fluorescein Angiography/methods Severity of Illness Index Tomography Optical Coherence/methods Macular Degeneration chemistry.chemical_compound 0302 clinical medicine lcsh:Ophthalmology Macular Degeneration/diagnosis Photopigment Fluorescein Angiography 610 Medicine & health RPE tear Aged 80 and over General Medicine medicine.anatomical_structure Female RPE-aperture Geographic atrophy medicine.symptom Tomography Optical Coherence Research Article Photoreceptor Cells Vertebrate Visual phototransduction medicine.medical_specialty Fundus Oculi 03 medical and health sciences Ophthalmology medicine Humans Aged Retrospective Studies Retina Retinal pigment epithelium Photoreceptor Cells Vertebrate/pathology Photoreceptor business.industry Age-related macular degeneration Retinal Macular degeneration medicine.disease eye diseases chemistry lcsh:RE1-994 030221 ophthalmology & optometry sense organs business 030217 neurology & neurosurgery Follow-Up Studies |
| Zdroj: | Giannakaki-Zimmermann, Helena; Querques, Giuseppe; Munch, Inger Christine; Shroff, Daraius; Sarraf, David; Chen, Xuejing; Cunha-Souza, Eduardo; Mrejen, Sarah; Capuano, Vittorio; Rodrigues, Murilo W; Gupta, Charu; Ebneter, Andreas; Zinkernagel, Martin; Munk, Marion (2017). Atypical retinal pigment epithelial defects with retained photoreceptor layers: a so far disregarded finding in age related macular degeneration. BMC ophthalmology, 17(1), p. 67. BioMed Central 10.1186/s12886-017-0452-0 BMC Ophthalmology, Vol 17, Iss 1, Pp 1-8 (2017) Giannakaki-Zimmermann, H, Querques, G, Munch, I C, Shroff, D, Sarraf, D, Chen, X, Cunha-Souza, E, Mrejen, S, Capuano, V, Rodrigues, M W, Gupta, C, Ebneter, A, Zinkernagel, M S & Munk, M R 2017, ' Atypical retinal pigment epithelial defects with retained photoreceptor layers : a so far disregarded finding in age related macular degeneration ', B M C Ophthalmology, vol. 17, 67 . https://doi.org/10.1186/s12886-017-0452-0 BMC Ophthalmology |
| DOI: | 10.1186/s12886-017-0452-0 |
| Popis: | BACKGROUND: To report patients with age-related macular degeneration and atypical central retinal pigment epithelium (RPE) defects not attributable to geographic atrophy (GA) or RPE-tears with overlying preserved photoreceptor layers.METHODS: Multimodal imaging case-series evaluating the course of atypical RPE- defects in patients with AMD using Color fundus images, Optical coherence tomography (OCT), OCT-Angiography, fundus autofluorescence (FAF) and fluorescein-angiography (FA).RESULTS: Ten patients were identified. Three patients had a prior RPE-rip and were excluded. Seven patients with a mean follow-up period of 47 ± 38 months after the occurrence of the RPE-defect were included (age range 71-87 years). Mean distance Best corrected visual acuity (BCVA) at initial presentation was 0.36 ± 0.29logMAR and at last follow-up visit 0.51 ± 0.43logMAR. Patients presented with clinically apparent GA on funduscopy and FAF, but preserved photoreceptor layers on optical coherence tomography (OCT). On FA there was early hyperfluorescence and late pooling visible. Over time, migration of RPE/drusenoid material right above the Bruch's membrane with concomitant decrease of hypoautofluorescence was detectable in 4 cases. An enlargement of the RPE-defect was apparent in the remaining 3 cases. The majority (n = 4) showed a drusenoid pigment epithelium detachment (PED) preceding the lesion.CONCLUSIONS: Beside GA and characteristic RPE-tears, another atypical form of RPE-defect with overlying preserved photoreceptor layers are found in AMD. This so far disregarded subgroup of patients present with reasonable visual function and long-term survival of photoreceptors layers. Repair mechanisms such as ingrowth of RPE/drusenoid material and persistent subretinal fluid (SRF), but also a RPE-independent visual cycle for cone photopigment within the neurosensory retina may contribute to their favorable course. |
| Databáze: | OpenAIRE |
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