L'immunothérapie antirabique passive d'hier et d'aujourd'hui
| Autor: | Florence Ribadeau-Dumas, Laurent Dacheux, Hervé Bourhy |
|---|---|
| Přispěvatelé: | Centre National de Référence de la Rage-Dynamique des Lyssavirus et adaptation à l'hôte (CNR), Institut Pasteur [Paris], Centre Collaborateur de l'OMS pour la Rage - Dynamique des lyssavirus et adaptation à l'hôte (CC-OMS), Institut Pasteur [Paris] (IP) |
| Jazyk: | francouzština |
| Rok vydání: | 2010 |
| Předmět: |
History
Passive medicine.disease_cause Active immunization 0302 clinical medicine MESH: Animals 030212 general & internal medicine MESH: Developing Countries 0303 health sciences biology MESH: Rabies Vaccines 21st Century 3. Good health MESH: Rabies virus 20th Century [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology MESH: Immunization Passive MESH: History 20th Century Viral disease Antibody MESH: History 21st Century MESH: Immune Tolerance Rabies General Biochemistry Genetics and Molecular Biology 03 medical and health sciences MESH: Rabies medicine Immune Tolerance Humans Animals Horses Adverse effect MESH: Horses Developing Countries 030304 developmental biology 19th Century MESH: Humans business.industry Rabies virus medicine.disease Regimen Immunization Rabies Vaccines Immunology biology.protein MESH: History 19th Century Horse Diseases business MESH: Horse Diseases |
| Zdroj: | Biologie Aujourd'hui Biologie Aujourd'hui, EDP sciences, 2010, 204 (1), pp.71-80. ⟨10.1051/jbio/2009049⟩ Biologie Aujourd'hui, 2010, 204 (1), pp.71-80. ⟨10.1051/jbio/2009049⟩ |
| ISSN: | 2105-0678 2105-0686 |
| DOI: | 10.1051/jbio/2009049⟩ |
| Popis: | International audience; Rabies is a fatal disease transmitted by infected animals by bite, scratch, licking on broken skin or contamination of mucosis by saliva. The regimen of post-exposure prophylaxis for people not previously vaccinated, that is currently recommended by WHO, consists of a combination of wound cleaning, active immunization and passive immunization when the exposure is of category 3. Most of the products available on the market, in particular human rabies immunoglobulins, highly purified equine rabies immunoglobulins and the derived F(ab')(2) fragments, are now characterized by high potency and safety. Although the interest of passive anti-rabies immunization was first demonstrated in the first half of the 20th century, there is still an inadequate supply of these products to the target populations mostly in developing countries. Therefore, it is urgent to set-up training and information actions for healthcare personnel on the need to use passive immunotherapy and the lack of adverse effects of the related products. For the future, we hope that a scale up of production and a lower price will improve the accessibility to these products. The development of new products based on monoclonal antibodies and molecular biology, and which may be cheaper, is promising. |
| Databáze: | OpenAIRE |
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