Late lumen loss and intima hyperplasia after sirolimus-eluting and zotarolimus-eluting stent implantation in diabetic patients: the diabetes and drug-eluting stent (DiabeDES III) angiography and intravascular ultrasound trial
| Autor: | Evald Hoej Christiansen, Jan Ravkilde, Hans-Henrik Tilsted, Anton Boel Villadsen, Lars Romer Krusell, Per Thayssen, Lisette Okkels Jensen, Knud Erik Pedersen, Michael Maeng, Hans Erik Bøtker, Jens Flensted Lassen, Knud Noerregaard Hansen, Thomas Vesterlund, Leif Thuesen, Jens Aarøe |
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| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
Male
medicine.medical_specialty Angioplasty Balloon Laser-Assisted medicine.medical_treatment Urology Coronary Artery Disease Coronary Angiography Coronary Restenosis Diabetes Complications Restenosis Risk Factors Angioplasty Neointima Intravascular ultrasound Coronary stent medicine Humans Zotarolimus Single-Blind Method cardiovascular diseases Ultrasonography Interventional Aged Neointimal hyperplasia Sirolimus Hyperplasia medicine.diagnostic_test business.industry Stent Drug-Eluting Stents Middle Aged medicine.disease equipment and supplies surgical procedures operative Treatment Outcome Drug-eluting stent cardiovascular system Female Radiology Cardiology and Cardiovascular Medicine business medicine.drug Follow-Up Studies |
| Zdroj: | Jensen, L O, Maeng, M, Thayssen, P, Villadsen, A, Krusell, L R, Botker, H E, Pedersen, K E, Aaroe, J, Christiansen, E H, Vesterlund, T, Hansen, K N, Ravkilde, J, Hansen, H-H T, Lassen, J F & Thuesen, L 2011, ' Late lumen loss and intima hyperplasia after sirolimus-eluting and zotarolimus-eluting stent implantation in diabetic patients: the diabetes and drug-eluting stent (DiabeDES III) angiography and intravascular ultrasound trial ', EuroIntervention, vol. 7, no. 3, pp. 323-31 . https://doi.org/10.4244/EIJV7I3A56 Jensen, L O, Mæng, M, Thayssen, P, Boel Villadsen, A, Krusell, L R, Botker, H E, Pedersen, K E, Aaroe, J, Christiansen, E H, Vesterlund, T, Hansen, K N, Ravkilde, J, Hansen, H-H T, Lassen, J F & Thuesen, L 2011, ' Late lumen loss and intima hyperplasia after sirolimus-eluting and zotarolimus-eluting stent implantation in diabetic patients: the diabetes and drug-eluting stent (DiabeDES III) angiography and intravascular ultrasound trial ', EuroIntervention, vol. 7, no. 3, pp. 323-31 . https://doi.org/10.4244/EIJV7I3A56 |
| Popis: | Aims: Patients with diabetes mellitus have increased risk of in-stent restenosis after coronary stent implantation due to neointimal hyperplasia (NIH). The aim of this study was to use quantitative coronary angiography (QCA) and volumetric intravascular ultrasound (IVUS) to evaluate the effects of the sirolimus-eluting Cypher ® stent (SES) and the zotarolimus-eluting Endeavor ® stent (ZES) on angiographic late lumen loss and intima hyperplasia in diabetic patients. Methods and results: In the DiabeDES III trial, 127 patients were randomised to SES or ZES stent implantation. Angiographic 10-month follow-up data were available in 105 patients, including 48 SES and 57 ZES treated patients. Angiographic endpoints were in-stent late lumen loss and minimal lumen diameter. IVUS endpoints included NIH volume and in-stent percent volume obstruction. Baseline clinical characteristics and lesion parameters were similar in the two groups. At 10-month follow-up, angiographic in-stent late lumen loss (0.14±0.37 mm vs. 0.74±0.45 mm, p |
| Databáze: | OpenAIRE |
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