Brain connectomic associations with traditional Chinese medicine diagnostic classification of major depressive disorder: a diffusion tensor imaging study
Autor: | Yuan-Yuan Zhang, Zhu Chunqing, Lan-Ying Liu, Li Yaping, Pei-Rong Wang, Xiaopei Xu, Edward S. Hui, Chun-Yu Yang, Gang Wang, Li-Yuan Luo, Hong-Tao Hou, Zhang-Jin Zhang, Yu-Lin Cao |
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Jazyk: | angličtina |
Rok vydání: | 2019 |
Předmět: |
Oncology
medicine.medical_specialty Major depressive disorder 01 natural sciences White matter Angular gyrus 03 medical and health sciences 0302 clinical medicine Traditional Chinese medicine Gyrus Internal medicine medicine Connectome Pharmacology business.industry Research lcsh:Other systems of medicine medicine.disease Classification lcsh:RZ201-999 030205 complementary & alternative medicine 0104 chemical sciences Calcarine sulcus 010404 medicinal & biomolecular chemistry medicine.anatomical_structure Diffusion tensor imaging Complementary and alternative medicine nervous system business Insula Parahippocampal gyrus |
Zdroj: | Chinese Medicine, Vol 14, Iss 1, Pp 1-10 (2019) Chinese Medicine |
ISSN: | 1749-8546 |
DOI: | 10.1186/s13020-019-0239-8 |
Popis: | Background Major depressive disorder (MDD) is highly heterogeneous in pathogenesis and manifestations. Further classification may help characterize its heterogeneity. We previously have shown differential metabolomic profiles of traditional Chinese medicine (TCM) diagnostic subtypes of MDD. We further determined brain connectomic associations with TCM subtypes of MDD. Methods In this naturalistic study, 44 medication-free patients with a recurrent depressive episode were classified into liver qi stagnation (LQS, n = 26) and Heart and Spleen Deficiency (HSD, n = 18) subtypes according to TCM diagnosis. Healthy subjects (n = 28) were included as controls. Whole-brain white matter connectivity was analyzed on diffusion tensor imaging. Results The LQS subtype showed significant differences in multiple network metrics of the angular gyrus, middle occipital gyrus, calcarine sulcus, and Heschl’s gyrus compared to the other two groups. The HSD subtype had markedly greater regional connectivity of the insula, parahippocampal gyrus, and posterior cingulate gyrus than the other two groups, and microstructural abnormalities of the frontal medial orbital gyrus and middle temporal pole. The insular betweenness centrality was strongly inversely correlated with the severity of depression and dichotomized the two subtypes at the optimal cutoff value with acceptable sensitivity and specificity. Conclusions The LQS subtype is mainly characterized by aberrant connectivity of the audiovisual perception-related temporal-occipital network, whereas the HSD subtype is more closely associated with hyperconnectivity and microstructural abnormalities of the limbic-paralimbic network. Insular connectivity may serve a biomarker for TCM-based classification of depression. Trial registration Registered at http://www.clinicaltrials.gov (NCT02346682) on January 27, 2015 |
Databáze: | OpenAIRE |
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