Impact of pretreatment whole-tumor perfusion computed tomography and 18F-fluorodeoxyglucose positron emission tomography/computed tomography measurements on local control of non-small cell lung cancer treated with stereotactic body radiotherapy
| Autor: | Tamaki Fujita, Hiroyuki Miura, Mitsuki Tanaka, Katsumi Hirose, Hiroko Seino, Hiromasa Fujita, Yoshihiro Takai, Hideo Kawaguchi, Shinya Kakehata, Masahiko Aoki, Fumiyasu Tsushima, Mariko Sato, Ichitaro Fujioka, Shuichi Ono, Yoshiomi Hatayama, H. Akimoto |
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| Rok vydání: | 2016 |
| Předmět: |
Male
medicine.medical_specialty Lung Neoplasms Health Toxicology and Mutagenesis medicine.medical_treatment Standardized uptake value Kaplan-Meier Estimate Radiosurgery dual-energy CT 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine non–small cell lung cancer Fluorodeoxyglucose F18 Carcinoma Non-Small-Cell Lung Positron Emission Tomography Computed Tomography medicine Regular Paper Humans average iodine density Radiology Nuclear Medicine and imaging Lung cancer Aged Fluorodeoxyglucose Aged 80 and over Radiation medicine.diagnostic_test business.industry SUVmax Middle Aged medicine.disease FDG-PET/CT Radiation therapy Perfusion stereotactic body radiotherapy 030220 oncology & carcinogenesis Multivariate Analysis Adenocarcinoma Female Radiology Neoplasm Recurrence Local business Nuclear medicine Emission computed tomography medicine.drug |
| Zdroj: | Journal of Radiation Research |
| ISSN: | 1349-9157 |
| Popis: | This study aimed to investigate the correlation between the average iodine density (AID) detected by dual-energy computed tomography (DE-CT) and the maximum standardized uptake value (SUVmax) yielded by [18F] fluorodeoxyglucose positron emission tomography (18F-FDG PET) for non–small cell lung cancer (NSCLC) treated with stereotactic body radiotherapy (SBRT). Seventy-four patients with medically inoperable NSCLC who underwent both DE-CT and 18F-FDG PET/CT before SBRT (50‒60 Gy in 5‒6 fractions) were followed up after a median interval of 24.5 months. Kaplan–Meier analysis was used to determine associations between local control (LC) and variables, including AID, SUVmax, tumor size, histology, and prescribed dose. The median AID and SUVmax were 18.64 (range, 1.18–45.31) (100 µg/cm3) and 3.2 (range, 0.7–17.6), respectively. No correlation was observed between AID and SUVmax. Two-year LC rates were 96.2% vs 75.0% (P = 0.039) and 72.0% vs 96.2% (P = 0.002) for patients classified according to high vs low AID or SUVmax, respectively. Two-year LC rates for patients with adenocarcinoma vs squamous cell carcinoma vs unknown cancer were 96.4% vs 67.1% vs 92.9% (P = 0.008), respectively. Multivariate analysis identified SUVmax as a significant predictor of LC. The 2-year LC rate was only 48.5% in the subgroup of lower AID and higher SUVmax vs >90% (range, 94.4–100%) in other subgroups (P = 0.000). Despite the short follow-up period, a reduction in AID and subsequent increase in SUVmax correlated significantly with local failure in SBRT-treated NSCLC patients. Further studies involving larger populations and longer follow-up periods are needed to confirm these results. |
| Databáze: | OpenAIRE |
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