Diurnal variation of plasma corticosterone in depression
| Autor: | Christopher R. W. Edwards, Guy M. Goodwin, Jill C. Campbell, Lawrence J. Whalley, J. E. Christie, Jonathan R. Seckl, George Fink |
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| Rok vydání: | 1990 |
| Předmět: |
Adult
endocrine system medicine.medical_specialty Evening Adolescent Endocrinology Diabetes and Metabolism Alcohol and cortisol Endogeny chemistry.chemical_compound Endocrinology Adrenocorticotropic Hormone Corticosterone Internal medicine medicine Humans Biological Psychiatry Depression (differential diagnoses) Depressive Disorder Endocrine and Autonomic Systems business.industry Diurnal temperature variation Middle Aged Control subjects Circadian Rhythm Psychiatry and Mental health chemistry Female Plasma corticosterone business hormones hormone substitutes and hormone antagonists |
| Zdroj: | Psychoneuroendocrinology. 15:485-488 |
| ISSN: | 0306-4530 |
| DOI: | 10.1016/0306-4530(90)90071-g |
| Popis: | Hypersecretion of cortisol is associated with depression. Because corticosterone may show greater responsiveness than cortisol to exogenous ACTH in depression and it has behavioural effects in rodents, we determined whether depression is also associated with hypersecretion of corticosterone. Both cortisol and corticosterone were significantly elevated in depression, with greatest differences from control subjects during the afternoon and evening. The ratio of corticosterone/cortisol was constant and similar throughout the day in both depressed patients and controls. We conclude that there is no disproportionate endogenous hypersecretion of corticosterone in depression. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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