Molecular Cross-Talk between Gravity- and Light-Sensing Mechanisms in Euglena gracilis
| Autor: | Adeel Nasir, Peter Rolf Richter, Aude Le Bail, Viktor Daiker, Julia Stoltze, Binod Prasad, Sebastian Michael Strauch, Michael Lebert |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: |
Inorganic Chemistry
ddc:570 Organic Chemistry General Medicine Physical and Theoretical Chemistry Molecular Biology Spectroscopy Catalysis Euglena gracilis phototaxis gravitaxis photoactivated adenylyl cyclase protein kinase A RNA interference indirect immuno-fluorescent assay movement analysis Computer Science Applications |
| Zdroj: | International Journal of Molecular Sciences; Volume 23; Issue 5; Pages: 2776 |
| ISSN: | 1422-0067 |
| DOI: | 10.3390/ijms23052776 |
| Popis: | Euglena gracilis is a photosynthetic flagellate. To acquire a suitable position in its surrounding aquatic environment, it exploits light and gravity primarily as environmental cues. Several physiological studies have indicated a fine-tuned relationship between gravity sensing (gravitaxis) and light sensing in E. gracilis. However, the underlying molecular mechanism is largely unknown. The photoreceptor photoactivated adenylyl cyclase (PAC) has been studied for over a decade. Nevertheless, no direct/indirect interaction partner (upstream/downstream) has been reported for PAC. It has been shown that a specific protein, kinase A (PKA), showed to be involved in phototaxis and gravitaxis. The current study reports the localization of the specific PKA and its relationship with PAC. |
| Databáze: | OpenAIRE |
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