Oxidative damage and schizophrenia: the potential benefit by atypical antipsychotics
| Autor: | Anand Saoji, Linesh Khobragade, Suchet D. Khanzode, Avinash Turankar, Ganesh N. Dakhale, Shruti S. Khanzode |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Adult
Male Psychosis medicine.medical_specialty medicine.drug_class medicine.medical_treatment Atypical antipsychotic Ascorbic Acid Lipid peroxidation chemistry.chemical_compound Internal medicine Malondialdehyde Brief Psychiatric Rating Scale medicine Humans Prospective Studies Antipsychotic Biological Psychiatry Chi-Square Distribution Superoxide Dismutase Middle Aged medicine.disease Ascorbic acid Psychiatry and Mental health Oxidative Stress Neuropsychology and Physiological Psychology Endocrinology chemistry Biochemistry Schizophrenia Case-Control Studies Female Psychology Antipsychotic Agents |
| Zdroj: | Neuropsychobiology. 49(4) |
| ISSN: | 0302-282X |
| Popis: | There is evidence to suggest the derangement of the oxidant and antioxidant defense system in schizophrenia. The present study examined the effect of atypical antipsychotics on lipid peroxidation, superoxide dismutase (SOD) and ascorbic acid. For this purpose, a prospective, open-label, 8-week study design was utilized. Serum SOD, serum malondialdehyde (MDA) and plasma ascorbic acid were estimated. Schizophrenic patients (n = 48) were compared with age- and sex-matched healthy volunteers (n = 40). There was a significant increase in serum SOD, serum MDA and a decrease in plasma ascorbic acid in schizophrenic patients as compared to control subjects. The trend altered significantly after the treatment with atypical antipsychotics. The results of the Brief Psychiatric Rating Scale for schizophrenia also improved with the treatment. The findings indicate an involvement of free radicals in schizophrenia and its modification by treatment with atypical antipsychotics. This study can also be used as a predictor of drug response by atypical antipsychotics in schizophrenia. |
| Databáze: | OpenAIRE |
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