Lycopene has reduced renal damage histopathologically and biochemically in experimental renal ischemia-reperfusion injury

Autor:	Faik Kose, Zafer Turkyilmaz, Abdullah Can Basaklar, Cem Kaya, Kaan Sönmez, Ramazan Karabulut, Ozlem Gulbahar, Gamze Kulduk
Rok vydání:	2015
Předmět:	medicine.medical_specialty Antioxidant medicine.medical_treatment Ischemia Urology Critical Care and Intensive Care Medicine Antioxidants Blood Urea Nitrogen chemistry.chemical_compound Lycopene Laparotomy Malondialdehyde medicine Animals Rats Wistar Creatinine Renal ischemia business.industry Therapeutic effect General Medicine Glutathione medicine.disease Carotenoids Rats Disease Models Animal Kidney Tubules chemistry Nephrology Anesthesia Reperfusion Injury Female business
Zdroj:	Renal failure. 37(8)
ISSN:	1525-6049
Popis:	Background: The present study aimed to investigate whether the inflammatory and antioxidant lycopene has a therapeutic effect against renal ischemia/reperfusion (I/R) injury. Materials and methods: In this study, 24 Wistar-Albino rats, weighing from 200 to 250g, were divided into four groups. All rats underwent median laparotomy under anesthesia. No procedures were performed in the control group (Group C), whereas 100 mg/kg lycopene was administered by gavage in the lycopene group (Group L). The arteries of both kidneys were clamped for 45 min in the ischemia group (Group I), whereas 100 mg/kg lycopene was administered by gavage 30 min before clamping renal arteries, and ischemia was performed in the treatment group (Group T) rats. For all rats, blood samples and renal tissues were collected at 6 h of reperfusion. Samples were used to examine serum BUN, creatinine, MDA and GSH levels, and the renal tissues were used to examine MDA and GSH levels, and renal histopathologies. Results: The treatment group had statistically significant lower serum MDA levels, histopathological tubular vacuolization, loss of brush border and tubular dilatation (p0.05). Conclusion: The present study demonstrated that lycopene, which was administered prior to renal I/R injury, prevented renal damage through biochemical and histopathological parameters.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b64234fffd91ebd6482db0c3d9493f56 https://pubmed.ncbi.nlm.nih.gov/26161692 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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