Successful treatment of childhood prolonged refractory status epilepticus with lacosamide
| Autor: | Zheng Fan, Yael Shiloh-Malawsky, Michael B. Tennison, Robert S. Greenwood |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Male
Lacosamide animal diseases Clinical Neurology Antiepileptic drug Status epilepticus Epilepsy Status Epilepticus Refractory Acetamides Humans Medicine Refractory status epilepticus heterocyclic compounds Child Clinical syndrome business.industry General Medicine medicine.disease Seizure nervous system diseases Treatment Treatment Outcome nervous system Neurology Anesthesia Severe morbidity Anticonvulsants Neurology (clinical) medicine.symptom business medicine.drug |
| Zdroj: | Seizure. 20:586-588 |
| ISSN: | 1059-1311 |
| Popis: | Prolonged, refractory status epilepticus is a rare clinical syndrome that is associated with severe morbidity and mortality. Lacosamide is a newly approved medication for treatment of partial onset seizures in adults, which has a novel mechanism of action. Experimental data and recent reports suggest that lacosamide could be effective in status epilepticus. We report a child with prolonged, refractory status epilepticus that persisted for 10 weeks despite treatment with multiple anti-epileptics and anesthetics and was then aborted with lacosamide. This is the first report of the effect of lacosamide in prolonged refractory status epilepticus, and the first report of lacosamide efficacy in status epilepticus in a child. |
| Databáze: | OpenAIRE |
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