Diaphragmatic fatigue is associated with decreased inositol 1,4,5-trisphosphate formation
| Autor: | Phillips K, McNatt L, Anderson Wm, James H. Zavecz |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
inorganic chemicals
Pulmonary and Respiratory Medicine medicine.medical_specialty Diaphragm Diaphragmatic breathing Inositol 1 4 5-Trisphosphate Biology In Vitro Techniques chemistry.chemical_compound Internal medicine medicine Respiratory muscle Animals Inositol Maximal contraction Respiratory system Rats Inbred Strains musculoskeletal system Rats carbohydrates (lipids) Endocrinology chemistry embryonic structures Second messenger system Rat Diaphragm sense organs medicine.symptom Muscle contraction Muscle Contraction |
| Zdroj: | The American review of respiratory disease. 141(3) |
| ISSN: | 0003-0805 |
| Popis: | The ability of the rat diaphragm to produce inositol 1,4,5-trisphosphate (InsP3) in response to a maximal contractile stimulus was determine in vitro in both fatigued and nonfatigued diaphragms. InsP3 was produced during a maximal contraction of the diaphragm. After inducing fatigue, there was a significant reduction in the production of InsP3 compared with that In nonfatigued muscle. The maximal force generated by the diaphragm was also decreased after fatigue. A significant positive linear correlation was found between the force developed by the diaphragm and the amount of InsP3 liberated. |
| Databáze: | OpenAIRE |
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