Influence of Ocular Tropicamide on Exercise Testing
| Autor: | Efraim Ben-Ari, Amos Pines, Ilana Gelernter, Yaacov Drory, Mordechai Averbuch, Jan J. Kellermann, Enrique Z. Fisman, Yoram Levo |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Adult
Male medicine.medical_treatment Stress testing Visual Acuity Hemodynamics Blood Pressure Reflex Pupillary Electrocardiography Tropicamide Heart Rate Heart rate medicine Humans Pharmacology (medical) Prospective Studies Prospective cohort study medicine.diagnostic_test business.industry Eye drop Middle Aged Blood pressure Anesthesia Exercise Test Female Ophthalmic Solutions Cardiology and Cardiovascular Medicine business medicine.drug |
| Zdroj: | Cardiology. 81:172-177 |
| ISSN: | 1421-9751 0008-6312 |
| Popis: | This study was aimed to evaluate the effects of tropicamide 0.5% eye drops on cardiovascular parameters during exercise testing. The study group included 154 healthy subjects (mean age: 44.7 +/- 8 years). The subjects were divided into three groups according to the size of the pupils at the onset of exercise: A: pupils not dilated (n = 27), B: pupils partially dilated (n = 90) and C: pupils widely dilated (n = 37). They were compared to 66 healthy controls (age 43.8 +/- 8) who did not receive the drops. Rest and exercise parameters were affected in groups A and B, while the results of group C resembled those of the controls: (a) resting heart rate -66.7, 66.6, 70.9 and 69.3, respectively (p = 0.03); (b) heart rate at 50 and 100 W - 104, 107, 110 and 111 (p = 0.01) and 131, 131, 137, 139, respectively (p = 0.01); and (c) peak systolic blood pressure - 192, 186, 183, 175; respectively (p = 0.004). Reanalyzing the data by scoring of visual impairment gave identical results. As a whole, the study group achieved higher work loads than the controls (126 vs. 119 W; p = 0.03). We conclude that the instillation of ocular tropicamide has definite effects on cardiovascular parameters, both at rest and during exercise. Mainly, patients showed a lower heart rate at the initial levels of exercise. However, at symptom-limited level, tropicamide does not influence a patient's ability to achieve the target heart rate, and stress testing results are not altered by the drug. |
| Databáze: | OpenAIRE |
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