The ESSEN study of childhood-onset schizophrenia: selected results
| Autor: | Gregor Volberg, G. Bunk, B. Röpcke, C. Eggers |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Male
medicine.medical_specialty Pediatrics Social withdrawal Adolescent mental disorders Developmental and Educational Psychology medicine Child and adolescent psychiatry Humans Psychiatry Child Childhood-Onset Schizophrenia Course of illness Age Factors General Medicine medicine.disease Social disability Psychiatry and Mental health Schizophrenia Pediatrics Perinatology and Child Health Female Schizophrenic Psychology Psychology Severe course Clinical record Social Adjustment Follow-Up Studies |
| Zdroj: | European childadolescent psychiatry. 8 |
| ISSN: | 1018-8827 |
| Popis: | Introduction: We present the results of a 42 year long-term follow-up of 44 patients (19 males, 25 females) with childhood-onset schizophrenia (COS, age at onset: 7–14 years) who could be traced for a second follow-up examination 27 years after the first follow-up. Method: Data from interviews, clinical records, premorbid and social disability assessments were evaluated for statistical analyses. The symptomatology observed during the whole course of illness was rediagnosed by DSM-IV criteria. Results: The paranoid, catatonic, and schizoaffectives subtypes appeared most frequently. There have been no gender differences in age of first psychiatric symptoms (AFS), AFPS, and age of first hospitalization. Kaplan-Meier’s survival-analysis carried out for AFPS with sex as the grouping factor revealed that the cumulative prevalence appears to be earlier in females (between 7 and 15 years) than in males (between 10 and 18 years). Of the 44 patients 50% had a continuing severe course. Patients with onset before 12 years of age were characterized by a chronic/insidious onset, marked premorbid abnormalities, and by a poorer remission. Premorbid features of social withdrawal and reluctance indicated a risk for social disability within the later course. Conclusion: COS, as a rare but severe variant of schizophrenia, frequently develops from premorbid social maladaptation to an insidious onset but is subsequently followed by a transition to a course and outcome not distinguishable from that of adult-onset schizophrenia. |
| Databáze: | OpenAIRE |
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