Novel pyrazolopiperazinone- and pyrrolopiperazinone-based MCH-R1 antagonists

Autor:	Ofer Reizes, Anny Odile Colson, José Méndez-Andino, Kenneth M. Meyers, Jennifer L. Paris, Karen M.B. Hodge, John August Wos, X. Eric Hu, Jeremy M. Howard, Cindy Obringer, Maria C. Mitchell, Martin E. Dowty
Rok vydání:	2007
Předmět:	Models Molecular Melanin-concentrating hormone Clinical Biochemistry Molecular Conformation Pharmaceutical Science Biochemistry Chemical synthesis Piperazines Biological Testing Pyrrolopiperazinone Radioligand Assay chemistry.chemical_compound Pyrazolopiperazinone Drug Discovery Receptor Serotonin 5-HT2C Humans Pyrroles Receptors Somatostatin Molecular Biology integumentary system Chemistry Organic Chemistry Nutritional status respiratory system In vitro Pyrazoles Molecular Medicine Indicators and Reagents Caco-2 Cells hormones hormone substitutes and hormone antagonists
Zdroj:	Bioorganic & Medicinal Chemistry Letters. 17:657-661
ISSN:	0960-894X
DOI:	10.1016/j.bmcl.2006.10.096
Popis:	The synthesis and biological testing of novel classes of potent melanin-concentrating hormone (MCH-R1) antagonists based on pyrazolopiperazinone and pyrrolopiperazinone scaffolds are described.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b63c13330f72f8b408838e3e9d397233 https://doi.org/10.1016/j.bmcl.2006.10.096 Zobrazit plný text záznamu Full Text from ScienceDirect