Association between Ki67 Index and Clinicopathological Features in Colorectal Cancer
| Autor: | Todd A. Braciak, Zhi-Tao Xiao, Pan Li, Fuat Oduncu, Qing-Jan Ou, Gong Chen |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Oncology Adult Male Cancer Research medicine.medical_specialty China Colorectal cancer Labeling index Risk Assessment Sensitivity and Specificity Disease-Free Survival 03 medical and health sciences Young Adult 0302 clinical medicine Internal medicine Germany Biomarkers Tumor Prevalence Medicine Humans Young adult Association (psychology) Survival rate Aged Neoplasm Staging Aged 80 and over business.industry Reproducibility of Results Hematology Middle Aged medicine.disease Prognosis Survival Rate 030104 developmental biology Ki-67 Antigen 030220 oncology & carcinogenesis Ki67 index Biomarker (medicine) Clinicopathological features Female business Colorectal Neoplasms |
| Zdroj: | Oncology research and treatment. 39(11) |
| ISSN: | 2296-5262 |
| Popis: | Background: Conflicting results have been reported about the association between the Ki67 labeling index (Ki67-Li) and clinical outcome in patients with colorectal cancer (CRC). Patients and Methods: Ki67 expression was assessed by immunohistochemistry (IHC) in 2,233 consecutive CRC cases. Results: We determined 992 cases to have a low and 1,241 cases to have a high Ki67-Li (representing an approximately 44-56% breakdown in distribution between low versus high patients designated by phenotype). Stage III patients with a high Ki67-Li had higher 3-year disease-free survival (DFS) and overall survival (OS) than those with a low Ki67-Li (DFS 70 vs. 61%; p = 0.02 and OS 75 vs. 64%; p = 0.008). We also found significantly improved 3-year progression-free survival (PFS) for stage IV patients in the high versus the low Ki67-Li group (PFS 14 vs. 10%; p = 0.02). Yet, we found no statistical differences in prognosis for stage I and II patients and in OS for stage IV patients between high versus low Ki67-Li (p > 0.05). Conclusion: Our results suggest that high Ki67-Li can be an independent prognostic biomarker to aid the assessment of patient outcomes in both stage III and IV CRC. |
| Databáze: | OpenAIRE |
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