Effect of central administration of the κ-opiate receptor agonist U 69.593 on neurohypophyseal hormone levels in blood and cerebrospinal fluid
| Autor: | S Janssen, B.J.M. Van de Heijning, J.C Frankhuijzen-Sierevogel, C. Maigret, Tj.B. Van Wimersma Greidanus |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Male
Agonist medicine.medical_specialty Vasopressin Pyrrolidines medicine.drug_class Benzeneacetamides Neuropeptide Dynorphin Oxytocin Dynorphins Cellular and Molecular Neuroscience chemistry.chemical_compound Endocrinology Pituitary Gland Posterior U-69 593 Internal medicine Animals Medicine Rats Wistar Receptor Analgesics Water Deprivation Endocrine and Autonomic Systems business.industry Receptors Opioid kappa beta-Endorphin General Medicine Rats Arginine Vasopressin Neurology chemistry Depression Chemical business hormones hormone substitutes and hormone antagonists medicine.drug Hormone |
| Zdroj: | Neuropeptides. 30:452-455 |
| ISSN: | 0143-4179 |
| DOI: | 10.1016/s0143-4179(96)90009-8 |
| Popis: | Intracerebroventricular (i.c.v.) administration of the kappa-opiate receptor agonist U 69.593 induces a rapid and short lasting suppression of oxytocin (OXT) levels in plasma of water deprived rats, whereas only a tendency towards a suppression of vasopressin (AVP) levels in plasma is observed. No change in neurohypophyseal hormone levels in CSF occurs following i.c.v. administration of U 69.593 at the various times points studied. It is concluded that, upon i.c.v. administration, the suppressive influence of U 69.593 is much weaker than that of the dynorphins and that neurophypophyseal hormone levels in CSF behave differently from those in the peripheral circulation. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect