Evaluation of Pancreatic Tissue Fluid Pressure and Pain in Chronic Pancreatitis: A Longitudinal Study
| Autor: | Madsen P, L. Borly, N. Ebbehøj, J Bülow, Rasmussen Sg |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Adult
Male Longitudinal study medicine.medical_specialty Drainage procedure Pancreatic disease Pain law.invention Intraoperative Period law Pressure medicine Humans Longitudinal Studies Postoperative Period Pancreatic tissue business.industry Gastroenterology Middle Aged medicine.disease Pathophysiology Surgery Pressure measurement medicine.anatomical_structure Pancreatitis Chronic Disease Drainage Female Extracellular Space business Pancreas |
| Zdroj: | Scandinavian Journal of Gastroenterology. 25:462-466 |
| ISSN: | 1502-7708 0036-5521 |
| DOI: | 10.3109/00365529009095516 |
| Popis: | Pancreatic tissue fluid pressure and pain were compared in a longitudinal study in nine patients undergoing drainage operations for pain in chronic pancreatitis. Pressure measurements were performed percutaneously before the operation, intraoperatively before and after the drainage procedure, and percutaneously at follow-up study 1 year after the operation. The pressures were compared with 2-week pain scores. The median predrainage pressures were increased (27 mm Hg; range, 19-34 mm Hg; normal, 7 mm Hg; range, 2-13 mm Hg). The drainage operations led to a 45% pressure decrease (range, 0-77%). At 1-year follow-up study the pressure was increased in the patients with recurrent pain, and there was a significant relation between pressure and pain (R = 0.85, p less than 0.02). Furthermore, patients with an intraoperative pressure decrease greater than 10 mm Hg had a pain-free postoperative period. The duration of the pain-free period was significantly related to the size of the intraoperative pressure decrease (R = 0.79, p less than 0.03). These results further suggest that there is a causal relationship between pancreatic tissue fluid pressure and pain in chronic pancreatitis and that the success of the drainage procedure may be predicted by intraoperative pancreatic tissue fluid pressure measurements. |
| Databáze: | OpenAIRE |
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