Protective effects of polysaccharide from Dendrobium nobile against ethanol-induced gastric damage in rats
| Autor: | Yi Zhang, Chaoyang Ma, Nana Mei, Wenping Lv, Zaixiang Lou, Hongxin Wang, GuoHua He |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Antioxidant medicine.medical_treatment Matrix metalloproteinase Pharmacology Southeast asian Polysaccharide Biochemistry Dendrobium nobile 03 medical and health sciences 0302 clinical medicine Polysaccharides Structural Biology Oral administration Epidermal growth factor medicine Animals Stomach Ulcer Molecular Biology chemistry.chemical_classification Plants Medicinal Ethanol biology Plant Extracts Chemistry Stomach General Medicine biology.organism_classification digestive system diseases Rats 030104 developmental biology Gastric Mucosa 030220 oncology & carcinogenesis Dendrobium Prostaglandin E |
| Zdroj: | International Journal of Biological Macromolecules. 107:230-235 |
| ISSN: | 0141-8130 |
| Popis: | Dendrobium nobile is a medicinal herb in traditional China and Southeast Asian countries. Employing a rat model of ethanol-induced gastric ulcer, we examined the protective effect of polysaccharide (JCP) extracted from Dendrobium nobile and explored the related mechanisms. Oral administration with 100mg/kg and 300mg/kg body weight JCP for days can significant prevent the formation of gastric ulcer. Moreover, JCP pretreatment could alleviate ethanol-induced histological damage, antioxidant activities, the level of epidermal growth factor, gastric concentration of prostaglandin E, and regulate the signaling pathways of mitogen-activated protein kinases and matrix metalloproteinases. This study investigated the ethanol-induced gastric ulcer protective effect of JCP for the first time, and elucidated that the protective mechanisms. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect