Mutations in the gene encoding pejvakin, a newly identified protein of the afferent auditory pathway, cause DFNB59 auditory neuropathy
| Autor: | Guy Van Camp, Francisco J. del Castillo, Lut Van Laer, Nir Ben-Tal, Paul Avan, Uri Ron, Christine Petit, Michel Leibovici, Vincent Michel, Asadollah Aghaie, Sedigheh Delmaghani, Dominique Weil, Francina Langa, G. Mark Lathrop |
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| Rok vydání: | 2006 |
| Předmět: |
Male
Auditory Pathways Hearing Loss Sensorineural Molecular Sequence Data Auditory neuropathy Cell Mutation Missense Genes Recessive Mice Transgenic Nerve Tissue Proteins Biology medicine.disease_cause Mice Afferent otorhinolaryngologic diseases Genetics medicine OTOF Animals Humans Amino Acid Sequence Nonsyndromic deafness Gene Mutation Base Sequence Chromosome Mapping Chromosome DNA Anatomy medicine.disease Pedigree medicine.anatomical_structure Chromosomes Human Pair 2 Ear Inner Female Neuroscience |
| Zdroj: | Nature genetics |
| ISSN: | 1546-1718 1061-4036 |
| Popis: | Auditory neuropathy is a particular type of hearing impairment in which neural transmission of the auditory signal is impaired, while cochlear outer hair cells remain functional. Here we report on DFNB59, a newly identified gene on chromosome 2q31.1-q31.3 mutated in four families segregating autosomal recessive auditory neuropathy. DFNB59 encodes pejvakin, a 352-residue protein. Pejvakin is a paralog of DFNA5, a protein of unknown function also involved in deafness. By immunohistofluorescence, pejvakin is detected in the cell bodies of neurons of the afferent auditory pathway. Furthermore, Dfnb59 knock-in mice, homozygous for the R183W variant identified in one DFNB59 family, show abnormal auditory brainstem responses indicative of neuronal dysfunction along the auditory pathway. Unlike previously described sensorineural deafness genes, all of which underlie cochlear cell pathologies, DFNB59 is the first human gene implicated in nonsyndromic deafness due to a neuronal defect. |
| Databáze: | OpenAIRE |
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