Improved tissue ingrowth and anchorage of expanded polytetrafluoroethylene by perforation: an experimental study in the rat
| Autor: | Robert P. Bleicodl, J.M. Schakenraad, Berend van der Lei, Roger K.J. Simmermacher |
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| Rok vydání: | 1991 |
| Předmět: |
Male
medicine.medical_specialty Materials science Dermatologic Surgical Procedures Perforation (oil well) Biophysics Biocompatible Materials Bioengineering Expanded polytetrafluoroethylene Biomaterials Abdominal wall chemistry.chemical_compound Tensile Strength Mechanical strength medicine Animals Aponeurosis Polytetrafluoroethylene Skin Soft tissue Prostheses and Implants Rats Surgery medicine.anatomical_structure chemistry Mechanics of Materials Ceramics and Composites Collagen Stress Mechanical Tissue ingrowth |
| Zdroj: | Biomaterials. 12:22-24 |
| ISSN: | 0142-9612 |
| DOI: | 10.1016/0142-9612(91)90126-u |
| Popis: | Although an explaned polytetrafluoroethylene patch is a suitable synthetic material to repair large abdominal wall defects, lack of tissue ingrowth into the patch may give rise to herniation at the fasciapatch interface. This study was undertaken to determine whether perforations and/or ethanol pretreatment improved tissue ingrowth into the polytetrafluorethylene patch. Patches were implanted subcutaneously in 12 rats and evaluated 6 wk ( n = 4) or 12 wk ( n = 8) after implantation. Tissue ingrowth was only demonstrated into perforated patches. Stress-strain measurements showed that perforation caused a 25% decrease in the mechanical strength of the material. It was concluded that perforation might improve the anchorage of the polytetrafluoroethylene patch to the adjacent aponeurosis and thereby prevent herniation when the polytetrafluoroethylene soft tissue patch was used for the repair of abdominal wall defects. |
| Databáze: | OpenAIRE |
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