Cutting edge: CD8+ T cell priming in the absence of NK cells leads to enhanced memory responses
| Autor: | Bojan Polić, Thierry Walzer, Biljana Zafirova, Eric Vivier, Alfonso Martín-Fontecha, Linda S. Klavinskis, Katrina Soderquest, Graham M. Lord |
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| Přispěvatelé: | King's College London School of Medicine at Guy's Hospital, Division of Immunology, Infection, and Inflammatory Diseases, Centre d'Immunologie de Marseille - Luminy (CIML), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), University of Rijeka School of Medicine, Department of Histology and Embryology, Service de Chirurgie, Assistance Publique - Hôpitaux de Marseille (APHM)-Hospices Civiles de Marseille-Hôpital de la Conception [CHU - APHM] (LA CONCEPTION), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU) |
| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
Melanoma
Experimental CD8-Positive T-Lymphocytes Lymphocyte Activation MESH: Mice Knockout Mice Interleukin 21 0302 clinical medicine MESH: Up-Regulation Immunology and Allergy Cytotoxic T cell MESH: Animals IL-2 receptor Cells Cultured Mice Knockout 0303 health sciences MESH: Pore Forming Cytotoxic Proteins Natural killer T cell MESH: CD8-Positive T-Lymphocytes Up-Regulation 3. Good health Cell biology Killer Cells Natural MESH: Melanoma Experimental medicine.anatomical_structure NK Cell Lectin-Like Receptor Subfamily K MESH: Immunologic Memory MESH: NK Cell Lectin-Like Receptor Subfamily K [SDV.IMM]Life Sciences [q-bio]/Immunology Female MESH: Cells Cultured Pore Forming Cytotoxic Proteins MESH: Killer Cells Natural MESH: Mice Transgenic T cell Immunology Mice Transgenic Biology Lymphocyte Depletion MESH: Coculture Techniques 03 medical and health sciences MESH: Mice Inbred C57BL medicine Animals Humans Antigen-presenting cell MESH: Lymphocyte Activation MESH: Mice 030304 developmental biology MESH: Lymphocyte Depletion Lymphokine-activated killer cell MESH: Humans Perforin NKG2D Coculture Techniques Mice Inbred C57BL Immunologic Memory MESH: Female 030215 immunology |
| Zdroj: | Journal of Immunology Journal of Immunology, 2011, 186 (6), pp.3304-8. ⟨10.4049/jimmunol.1004122⟩ Journal of Immunology, Publisher : Baltimore : Williams & Wilkins, c1950-. Latest Publisher : Bethesda, MD : American Association of Immunologists, 2011, 186 (6), pp.3304-8. ⟨10.4049/jimmunol.1004122⟩ |
| ISSN: | 0022-1767 1550-6606 |
| Popis: | It is uncertain whether NK cells modulate T cell memory differentiation. By using a genetic model that allows the selective depletion of NK cells, we show in this study that NK cells shape CD8+ T cell fate by killing recently activated CD8+ T cells in an NKG2D- and perforin-dependent manner. In the absence of NK cells, the differentiation of CD8+ T cells is strongly biased toward a central memory T cell phenotype. Although, on a per-cell basis, memory CD8+ T cells generated in the presence or the absence of NK cells have similar functional features and recall capabilities, NK cell deletion resulted in a significantly higher number of memory Ag-specific CD8+ T cells, leading to more effective control of tumors carrying model Ags. The enhanced memory responses induced by the transient deletion of NK cells may provide a rational basis for the design of new vaccination strategies. |
| Databáze: | OpenAIRE |
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