Experimental non-severe hypoglycaemia substantially impairs cognitive function in type 2 diabetes: a randomised crossover trial

Autor: Nicole Jacqueline Jensen, Marianne L Bergmann, Malin Nilsson, Jørgen Rungby, Michael Gejl, Mette Zander, Heidi Storgaard, Kamilla W. Miskowiak
Rok vydání: 2019
Předmět:
Zdroj: Nilsson, M, Jensen, N, Gejl, M, Bergmann, M L, Storgaard, H, Zander, M, Miskowiak, K & Rungby, J 2019, ' Experimental non-severe hypoglycaemia substantially impairs cognitive function in type 2 diabetes: a randomised crossover trial ', Diabetologia, vol. 62, no. 10, pp. 1948-1958 . https://doi.org/10.1007/s00125-019-4964-4
Nilsson, M, Jensen, N, Gejl, M, Bergmann, M L, Storgaard, H, Zander, M, Miskowiak, K & Rungby, J 2019, ' Experimental non-severe hypoglycaemia substantially impairs cognitive function in type 2 diabetes : a randomised crossover trial ', Diabetologia, vol. 62, no. 10, pp. 1948-1958 . https://doi.org/10.1007/s00125-019-4964-4
ISSN: 1432-0428
Popis: AIMS/HYPOTHESIS: Previous studies have demonstrated a relationship between cognitive impairment and hypoglycaemia (METHODS: In this randomised crossover study, 25 participants with type 2 diabetes attended two experimental visits with hyperinsulinaemic glucose clamping: one hypoglycaemic clamp (plasma glucose 3.0 ± 0.2 mmol/l) and one euglycaemic clamp (plasma glucose 6.0 ± 0.2 mmol/l). Participants were eligible if their diabetes was treated with diet or glucose-lowering medications (except sulfonylureas or insulin), age was 35-70 years, BMI was 23-35 kg/m2 and HbA1c was below 75 mmol/mol (9%). Cognitive function was assessed with a neurocognitive test battery measuring verbal memory, executive function, sustained attention and psychomotor speed. From the examined cognitive domains, a global cognition score was constructed estimating global cognition. A measurement for psychomotor speed was selected as the primary outcome. Participants and people assessing the outcomes were blinded to group assignment.RESULTS: Cognitive performance was impaired during hypoglycaemia with a mean score in the primary outcome test, Symbol Digit Modalities Test measuring psychomotor speed, of 48.7 ± 9.8 (hypoglycaemia) vs 56.6 ± 12.0 (euglycaemia); i.e. a change of -7.9 points (95% CI -10.9, -4.9; p CONCLUSIONS/INTERPRETATION: Acute non-severe hypoglycaemia (mean plasma glucose 3.1 mmol/l) has a substantial negative impact on cognitive function in individuals with type 2 diabetes.TRIAL REGISTRATION: ClinicalTrials.gov NCT03014011.FUNDING: The study was supported in part by a research grant from the Investigator Initiated Studies Program of Merck Sharp & Dohme Corp (MSD-MA-NORD-007-01). The opinions expressed in this paper are those of the authors and do not necessarily represent those of Merck Sharp & Dohme Corp. Funding was also received from Skibsreder Per Henriksen, R. og hustrus Foundation, The Danish Alzheimer Foundation and Savværksejer Jeppe Juhl og hustrus Foundation.
Databáze: OpenAIRE
Externí odkaz: