Experimental non-severe hypoglycaemia substantially impairs cognitive function in type 2 diabetes: a randomised crossover trial
Autor: | Nicole Jacqueline Jensen, Marianne L Bergmann, Malin Nilsson, Jørgen Rungby, Michael Gejl, Mette Zander, Heidi Storgaard, Kamilla W. Miskowiak |
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Rok vydání: | 2019 |
Předmět: |
0301 basic medicine
Adult Male medicine.medical_specialty Endocrinology Diabetes and Metabolism 030209 endocrinology & metabolism Type 2 diabetes 03 medical and health sciences 0302 clinical medicine Cognition Internal medicine Diabetes mellitus Internal Medicine medicine Humans Hypoglycemic Agents Effects of sleep deprivation on cognitive performance Aged Psychomotor learning Cross-Over Studies business.industry Middle Aged medicine.disease Crossover study Hypoglycemia 030104 developmental biology Diabetes Mellitus Type 2 Female Cognitive function Verbal memory business Hypoglycaemia Neurocognitive |
Zdroj: | Nilsson, M, Jensen, N, Gejl, M, Bergmann, M L, Storgaard, H, Zander, M, Miskowiak, K & Rungby, J 2019, ' Experimental non-severe hypoglycaemia substantially impairs cognitive function in type 2 diabetes: a randomised crossover trial ', Diabetologia, vol. 62, no. 10, pp. 1948-1958 . https://doi.org/10.1007/s00125-019-4964-4 Nilsson, M, Jensen, N, Gejl, M, Bergmann, M L, Storgaard, H, Zander, M, Miskowiak, K & Rungby, J 2019, ' Experimental non-severe hypoglycaemia substantially impairs cognitive function in type 2 diabetes : a randomised crossover trial ', Diabetologia, vol. 62, no. 10, pp. 1948-1958 . https://doi.org/10.1007/s00125-019-4964-4 |
ISSN: | 1432-0428 |
Popis: | AIMS/HYPOTHESIS: Previous studies have demonstrated a relationship between cognitive impairment and hypoglycaemia (METHODS: In this randomised crossover study, 25 participants with type 2 diabetes attended two experimental visits with hyperinsulinaemic glucose clamping: one hypoglycaemic clamp (plasma glucose 3.0 ± 0.2 mmol/l) and one euglycaemic clamp (plasma glucose 6.0 ± 0.2 mmol/l). Participants were eligible if their diabetes was treated with diet or glucose-lowering medications (except sulfonylureas or insulin), age was 35-70 years, BMI was 23-35 kg/m2 and HbA1c was below 75 mmol/mol (9%). Cognitive function was assessed with a neurocognitive test battery measuring verbal memory, executive function, sustained attention and psychomotor speed. From the examined cognitive domains, a global cognition score was constructed estimating global cognition. A measurement for psychomotor speed was selected as the primary outcome. Participants and people assessing the outcomes were blinded to group assignment.RESULTS: Cognitive performance was impaired during hypoglycaemia with a mean score in the primary outcome test, Symbol Digit Modalities Test measuring psychomotor speed, of 48.7 ± 9.8 (hypoglycaemia) vs 56.6 ± 12.0 (euglycaemia); i.e. a change of -7.9 points (95% CI -10.9, -4.9; p CONCLUSIONS/INTERPRETATION: Acute non-severe hypoglycaemia (mean plasma glucose 3.1 mmol/l) has a substantial negative impact on cognitive function in individuals with type 2 diabetes.TRIAL REGISTRATION: ClinicalTrials.gov NCT03014011.FUNDING: The study was supported in part by a research grant from the Investigator Initiated Studies Program of Merck Sharp & Dohme Corp (MSD-MA-NORD-007-01). The opinions expressed in this paper are those of the authors and do not necessarily represent those of Merck Sharp & Dohme Corp. Funding was also received from Skibsreder Per Henriksen, R. og hustrus Foundation, The Danish Alzheimer Foundation and Savværksejer Jeppe Juhl og hustrus Foundation. |
Databáze: | OpenAIRE |
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