Hepatoprotective Effects of Zerumbone against Paracetamol-Induced Acute Hepatotoxicity in Rats
| Autor: | Nurul Farhana Jufri, Liow Say Lee, Saiful Ridzuan Karim, Asmah Hamid |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Necrosis paracetamol Pharmacology liver medicine.disease_cause 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine medicine zerumbone oxidative stress HEPATIC PROTEIN biology business.industry Wbc differential toxicity General Medicine biology.organism_classification Bioactive compound 030104 developmental biology Zingiber zerumbet chemistry 030220 oncology & carcinogenesis Toxicity Absolute neutrophil count Original Article medicine.symptom business Oxidative stress |
| Zdroj: | The Malaysian Journal of Medical Sciences : MJMS |
| ISSN: | 2180-4303 1394-195X |
| DOI: | 10.21315/mjms2018.25.2.7 |
| Popis: | Background Zerumbone (ZER) is a major bioactive compound of Zingiber zerumbet, a wild ginger plant that has been documented to have anti-proliferative, anti-inflammatory and anti-oxidant properties. To investigate its hepatoprotective potential, this study was designed to determine the treatment effects of ZER on acute hepatotoxicity induced by paracetamol (PCM) in rats. Methods The control group was administered with phosphate buffer solution (PBS) while the other two groups received PCM alone (1000 mg/kg) and PCM + 25 mg/kg ZER, respectively, at 0 h and 4 h after PCM injection. After 24 h, the blood and liver were collected for differential white blood cell count, liver histological observation and biochemical analysis including alanine aminotransferase (ALT), aspartate aminotransferase (AST), and total protein concentration in serum and liver. Results Treatment with ZER was found to significantly reduce ALT (P = 0.041), AST (P = 0.044) and total hepatic protein (P = 0.045) in comparison to PCM-induced rats. Rats treated with ZER exhibited the normal structure of hepatocytes with no vacuolisation or necrosis and showed significantly reduced neutrophil count (P = 0.037). This finding suggests its ability to suppress the inflammatory processes caused by PCM overdosage and decrease the hepatocytes tendency to go through necrotic processes. Conclusion ZER possessed protective activity against PCM-induced acute hepatotoxicity in a rat model. |
| Databáze: | OpenAIRE |
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