Serologic Status and SARS-CoV-2 Infection over 6 Months of Follow Up in Healthcare Workers in Chicago: A Cohort Study
| Autor: | Amisha Wallia, Charlesnika T. Evans, Benjamin J DeYoung, Teresa R. Zembower, Babafemi Taiwo, Alex Zhu, John T. Wilkins, Lisa R. Hirschhorn, Laura J. Rasmussen-Torvik, Elizabeth Gray, Joyce C. Ho, Mercedes R. Carnethon |
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| Rok vydání: | 2021 |
| Předmět: |
Microbiology (medical)
medicine.medical_specialty Epidemiology Health Personnel Rate ratio Serology Cohort Studies COVID-19 Testing Internal medicine medicine Humans Medical history Prospective Studies Prospective cohort study Chicago business.industry SARS-CoV-2 virus diseases COVID-19 Pneumonia Confidence interval Infectious Diseases Immunoglobulin G Reinfection Cohort Original Article Serostatus business Cohort study Follow-Up Studies |
| Zdroj: | Infection Control and Hospital Epidemiology |
| ISSN: | 1559-6834 0899-823X |
| Popis: | Objective:To determine the changes in severe acute respiratory coronavirus virus 2 (SARS-CoV-2) serologic status and SARS-CoV-2 infection rates in healthcare workers (HCWs) over 6-months of follow-up.Design:Prospective cohort study.Setting and participants:HCWs in the Chicago area.Methods:Cohort participants were recruited in May and June 2020 for baseline serology testing (Abbott anti-nucleocapsid IgG) and were then invited for follow-up serology testing 6 months later. Participants completed monthly online surveys that assessed demographics, medical history, coronavirus disease 2019 (COVID-19), and exposures to SARS-CoV-2. The electronic medical record was used to identify SARS-CoV-2 polymerase chain reaction (PCR) positivity during follow-up. Serologic conversion and SARS-CoV-2 infection or possible reinfection rates (cases per 10,000 person days) by antibody status at baseline and follow-up were assessed.Results:In total, 6,510 HCWs were followed for a total of 1,285,395 person days (median follow-up, 216 days). For participants who had baseline and follow-up serology checked, 285 (6.1%) of the 4,681 seronegative participants at baseline seroconverted to positive at follow-up; 138 (48%) of the 263 who were seropositive at baseline were seronegative at follow-up. When analyzed by baseline serostatus alone, 519 (8.4%) of 6,194 baseline seronegative participants had a positive PCR after baseline serology testing (4.25 per 10,000 person days). Of 316 participants who were seropositive at baseline, 8 (2.5%) met criteria for possible SARS-CoV-2 reinfection (ie, PCR positive >90 days after baseline serology) during follow-up, a rate of 1.27 per 10,000 days at risk. The adjusted rate ratio for possible reinfection in baseline seropositive compared to infection in baseline seronegative participants was 0.26 (95% confidence interval, 0.13–0.53).Conclusions:Seropositivity in HCWs is associated with moderate protection from future SARS-CoV-2 infection. |
| Databáze: | OpenAIRE |
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