| Autor: |
Oscar Calvillo-Argüelles, Alice Schoffel, José-Mario Capo-Chichi, Husam Abdel-Qadir, Andre Schuh, Montserrat Carrillo-Estrada, Shiying Liu, Vikas Gupta, Aaron D. Schimmer, Karen Yee, Liran I. Shlush, Pradeep Natarajan, Paaladinesh Thavendiranathan |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
JACC: CardioOncology. 4:38-49 |
| ISSN: |
2666-0873 |
| DOI: |
10.1016/j.jaccao.2021.11.008 |
| Popis: |
Clonal hematopoiesis of indeterminate potential (CHIP) is a novel cardiovascular disease (CVD) risk factor in individuals without acute myeloid leukemia (AML).The aim of this study was to examine the association between mutations associated with CHIP (CHIP-related mutations) identified in patients at AML diagnosis and the risk for cardiovascular events (CVEs).This was a retrospective cohort study of 623 patients with AML treated between 2015 and 2018 who underwent DNA analysis. Cause-specific hazard regression models were used to study the associations between pathogenic mutations in common CHIP-related genes (Patients were 64.6 ± 15.3 years of age, 265 (42.5%) were women, and 63% had at least 1 CHIP-related mutation. Those with CHIP-related mutations were older (69.2 ± 12.3 vs 56.6 ± 16.6 years;Among patients with AML treated with intensive chemotherapy, mutations in CHIP-related genes were associated with an increased risk for developing incident CVEs after AML diagnosis. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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