Narażenie na dym tytoniowy a uszkodzenie śródbłonka u chorych z zaawansowaną miażdżycą naczyń wieńcowych
| Autor: | Wojciech Jawień, Dorota Szpak, Ryszard Chrząszcz, Anetta Undas, Andrzej Grochowalski, Ewa Florek |
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| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
medicine.medical_specialty
Endothelium medicine.medical_treatment uszkodzenie śródbłonka cigarette smoking Gastroenterology Tobacco smoke endothelial dysfunction miażdżyca chemistry.chemical_compound kotynina Internal medicine Fibrinolysis Internal Medicine medicine Myocardial infarction cotinine Endothelial dysfunction business.industry medicine.disease choroba niedokrwienna medicine.anatomical_structure chemistry palenie tytoniu Anesthesia Plasminogen activator inhibitor-1 atherosclerosis business Cotinine Asymmetric dimethylarginine coronary artery disease |
| Popis: | INTRODUCTION Exposure to tobacco smoke is associated with a higher cardiovascular risk, especially in patients with coronary artery disease (CAD). OBJECTIVES The aim of the study was to evaluate the effect of active and passive tobacco smoking on the activity of endothelial markers in advanced atherosclerosis. PATIENTS AND METHODS We studied 181 consecutive patients with advanced CAD (53 women and 128 men) aged 60 ±8 years, including 102 active self‑declared smokers (56.3%). We determined plasma asymmetric dimethylarginine (ADMA), thrombomodulin (TM), and plasminogen activator inhibitor‑1 (PAI‑1) levels, along with serum cotinine concentrations as a marker of tobacco smoking. RESULTS Plasma ADMA levels were higher in active smokers compared with nonsmokers (0.60 ±0.09 μmol/l vs. 0.49 ±0.08 μmol/l, P |
| Databáze: | OpenAIRE |
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