Comparison of clinical and serological differences among juvenile-, adult-, and late-onset systemic lupus erythematosus in Korean patients

Autor:	Yi-Rang Yim, Tae-Jong Kim, Ji-Hyoun Kang, Lihui Wen, Don-Hee Park, Young-Lan Park, Kyung-Eun Lee, Jong-Un Lee, Sung-Ji Lee, Jung-Ho Choi, June Key Lee
Rok vydání:	2015
Předmět:	Adult Male medicine.medical_specialty Disease onset Adolescent Late onset Severity of Illness Index Serology Young Adult Rheumatology Internal medicine Republic of Korea Severity of illness Humans Lupus Erythematosus Systemic Medicine Juvenile Age of Onset Young adult Child Autoantibodies business.industry Age Factors Autoantibody Middle Aged Sjogren's Syndrome Immunology Female Age of onset business
Zdroj:	Lupus. 24:1342-1349
ISSN:	1477-0962 0961-2033
DOI:	10.1177/0961203315591024
Popis:	ObjectivesWe investigated whether systemic lupus erythematosus (SLE) patients could be distinguished based on the time of disease onset and, if so, whether the groups differed in their clinical and laboratory features in ethnically homogeneous Korean patients.MethodsWe enrolled 201 SLE patients with available clinical data at the time of onset of SLE from the lupus cohort at Chonnam National University Hospital. Sociodemographic, clinical, and laboratory data, including autoantibodies, and concomitant diseases were found at the time of diagnosis of SLE by reviewing patient charts. We divided SLE patients according to age at SLE diagnosis into three groups: juvenile-onset SLE (JSLE, diagnosed at ≤ 18 years), adult-onset SLE (ASLE, diagnosed at 19–50 years), and late-onset SLE (LSLE, diagnosed at >50 years), and compared baseline demographic, clinical, and relevant laboratory findings.ResultsOf the 201 patients, 27 (14.4%), 149 (74.1%), and 25 (12.4%) were JSLE, ASLE, and LSLE patients, respectively. Fever, oral ulcers, nephritis, anemia, and thrombocytopenia were more common in JSLE patients than ASLE or LSLE patients ( p ConclusionsOur results indicate that SLE patients present with different clinical and serological manifestations according to age at disease onset. JSLE patients have more severe disease activity and more frequent renal involvement and LSLE patients have milder disease activity, more commonly accompanied by Sjögren’s syndrome, at disease onset.
Databáze:	OpenAIRE
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