Novel Anti-Glycan Antibodies Related to Inflammatory Bowel Disease Diagnosis and Phenotype
| Autor: | Anne M. Griffiths, Mark S. Silverberg, A. Hillary Steinhart, Cynthia H. Seow, Nir Dotan, Gordon R. Greenberg, Joanne M. Stempak, Hui Lan, Wei Xu |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Adult
Male Immunoglobulin A medicine.medical_specialty Adolescent Enzyme-Linked Immunosorbent Assay Inflammatory bowel disease Gastroenterology Antibodies Antineutrophil Cytoplasmic Diagnosis Differential Young Adult Crohn Disease Polysaccharides Internal medicine medicine Humans Child Fluorescent Antibody Technique Indirect Aged Hepatology biology Panca business.industry Area under the curve Odds ratio Middle Aged Inflammatory Bowel Diseases medicine.disease biology.organism_classification Phenotype Ulcerative colitis ROC Curve Child Preschool Immunology biology.protein Colitis Ulcerative Female Antibody business |
| Zdroj: | The American Journal of Gastroenterology. 104:1426-1434 |
| ISSN: | 1572-0241 0002-9270 |
| DOI: | 10.1038/ajg.2009.79 |
| Popis: | OBJECTIVES We sought to evaluate whether two novel immunoglobulin A (IgA) cell wall polysaccharide antibodies, anti-laminarin (anti-L) and anti-chitin (anti-C), aid in the diagnosis and phenotype differentiation of Crohn's disease (CD) and ulcerative colitis (UC). METHODS A cohort of 818 individuals with inflammatory bowel disease (IBD; 517 CD and 301 UC) from two IBD tertiary referral centers, with median ages of 33 and 39 years, respectively, and disease duration of 8.9 years, were phenotyped using the Montreal classification, and analyzed for seven anti-glycan antibodies (gASCA (anti-Saccharomyces cerevisiae) IgG, gASCA IgA, anti-chitobioside (GlcNAc(beta1,4)GlcNAc(beta)), anti-laminaribioside (Glc(beta1,3)Glb(beta)), anti-mannobioside (Man(alpha1,3)Man(alpha)), anti-L, and anti-C) and perinuclear atypical neutrophil cytoplasmic antibodies (pANCA). RESULTS In the CD patient population, 73% were positive for >/=1 anti-glycan antibody. All glycan markers were specific for CD (85.4-97.7%) and more prevalent in CD vs. UC (P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|