Ghrelin as an acute-phase reactant during postoperative stress response
| Autor: | Martina Rosicka, P. Maruna, R. Gürlich |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Male
medicine.medical_specialty Time Factors Hydrocortisone Endocrinology Diabetes and Metabolism Clinical Biochemistry Biochemistry Proinflammatory cytokine Endocrinology Interquartile range Stress Physiological Internal medicine Abdomen medicine Humans Postoperative Period Prospective cohort study Aged Inflammation biology business.industry digestive oral and skin physiology Biochemistry (medical) C-reactive protein Acute-phase protein General Medicine Perioperative Fasting Middle Aged Adaptation Physiological Ghrelin Cholecystectomy Laparoscopic Surgical Procedures Operative biology.protein Cytokines Female business Colorectal Neoplasms Abdominal surgery Acute-Phase Proteins |
| Zdroj: | Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. 40(6) |
| ISSN: | 0018-5043 |
| Popis: | Ghrelin is a growth hormone-releasing peptide, discovered in 1999 by Kojima et al. Its potential role in inflammation and stress response is not yet clear. The purpose of this study was to characterize perioperative levels of circulating ghrelin in relation to different surgical procedures. The authors compared plasma ghrelin changes with cortisol, cytokines, and acute-phase proteins. The prospective study was performed on 22 patients with resection for colon cancer (group 1). Group 2, functioning as a comparative group, consisted of 22 patients with elective laparotomic cholecystectomy. Plasma concentrations of ghrelin, cortisol, tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta, IL-6, IL-8, soluble IL-2 receptor, C reactive protein, and alpha1-antitrypsin were estimated repeatedly during a 72-hour postoperative period. Data revealed significant elevation of plasma ghrelin 24 hours after resection of coli (median 508.0 ng/l, interquartile range 398.2-633.7 ng/l) in relation to both preoperative levels (317.6 ng/l, 253.4-355.1 ng/l, p |
| Databáze: | OpenAIRE |
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