Clinical Outcomes of an Innovative Cefazolin Delivery Program for MSSA Infections in OPAT

Autor: Laura Herrera-Hidalgo, Rafael Luque-Márquez, Aristides de Alarcon, Ana Belén Guisado-Gil, Belen Gutierrez-Gutierrez, Maria Dolores Navarro-Amuedo, Julia Praena-Segovia, Juan Manuel Carmona-Caballero, Elena Fraile-Ramos, Alicia Gutierrez-Valencia, Luis Eduardo Lopez-Cortes, Maria Victoria Gil-Navarro
Přispěvatelé: Instituto de Salud Carlos III
Rok vydání: 2022
Předmět:
Zdroj: Journal of Clinical Medicine; Volume 11; Issue 6; Pages: 1551
ISSN: 2077-0383
Popis: Cefazolin is a recommended treatment for methicillin-susceptible Staphylococcus aureus (MSSA) infections that has been successfully used in outpatient parenteral antibiotic therapy (OPAT) programs. The aim of this study was to assess the clinical outcomes of cefazolin delivered each day (Group 24) vs. every two days (Group 48) for MSSA infections in OPAT programs. It was a prospective observational study with retrospective analysis of a cohort of MSSA infections attended in OPAT. The primary outcome was treatment success, defined as completing the antimicrobial regimen without death, treatment discontinuation, or readmission during treatment and follow-up. A univariate and multivariate logistic regression model was built. A two-sided p < 0.05 was considered statistically significant. Of the 149 MSSA infections treated with cefazolin 2 g/8 h in OPATs, 94 and 55 patients were included in the delivery Group 24 and Group 48, respectively. Treatment failure and unplanned readmission rates were similar in both groups (11.7% vs. 7.3% p = 0.752 and 8.5% vs. 5.5% p = 0.491). There was a significant increase in vascular access complications in Group 24 (33.0%) with respect to Group 48 (7.3%) (p < 0.001). Treating uncomplicated MSSA infection with cefazolin home-delivered every two days through an OPAT program is not associated with an increased risk of treatment failure and entails a significant reduction in resource consumption compared to daily delivery.
The authors received no financial support for the research, authorship, and/or publication of this article. HHL and GGAB were supported by the Instituto de Salud Carlos III, Subprograma Rio Hortega (grant CM19/00152 and grant CM19/00029). GVA was supported by the Instituto de Salud Carlos III, Subprograma Miguel Servet (grant CP19/00159).
Databáze: OpenAIRE
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