Regulation of mTORC1 by amino acids
| Autor: | David M. Sabatini, Liron Bar-Peled |
|---|---|
| Přispěvatelé: | Massachusetts Institute of Technology. Department of Biology, Koch Institute for Integrative Cancer Research at MIT, Bar-Peled, Liron, Sabatini, David |
| Rok vydání: | 2014 |
| Předmět: |
GTPase
mTORC1 Mechanistic Target of Rapamycin Complex 1 Biology Article Lysosome medicine Animals Humans Amino Acids Folliculin Mechanistic target of rapamycin chemistry.chemical_classification TOR Serine-Threonine Kinases Cell Biology Amino acid Cell biology medicine.anatomical_structure chemistry Biochemistry Multiprotein Complexes biology.protein biological phenomena cell phenomena and immunity Signal transduction Lysosomes Signal Transduction |
| Zdroj: | PMC |
| ISSN: | 0962-8924 |
| Popis: | The mechanistic target of rapamycin complex I (mTORC1) is a central regulator of cellular and organismal growth, and hyperactivation of this pathway is implicated in the pathogenesis of many human diseases including cancer and diabetes. mTORC1 promotes growth in response to the availability of nutrients, such as amino acids, which drive mTORC1 to the lysosomal surface, its site of activation. How amino acid levels are communicated to mTORC1 is only recently coming to light by the discovery of a lysosome-based signaling system composed of Rags (Ras-related GTPases) and Ragulator v-ATPase, GATOR (GAP activity towards Rags), and folliculin (FLCN) complexes. Increased understanding of this pathway will not only provide insight into growth control but also into the human pathologies triggered by its deregulation. National Institutes of Health (U.S.) (CA103866) National Institutes of Health (U.S.) (AI473890 United States. Department of Defense (W81XWH-07-0448) |
| Databáze: | OpenAIRE |
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