Relationship among total tear IgE, specific serum IgE, and total serum IgE levels in patients with pollen-induced allergic conjunctivitis
Autor: | Eiichi Uchio, Yasuo Yamana, Satoshi Yamana |
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Jazyk: | angličtina |
Rok vydání: | 2021 |
Předmět: |
Conjunctiva
Pollen-induced allergic conjunctivitis medicine.disease_cause Immunoglobulin E Food-induced allergic conjunctivitis Cellular and Molecular Neuroscience Antigen Pollen medicine Humans Total tear IgE Pathological Sensitization Conjunctivitis Allergic Specific serum IgE biology business.industry Inflammatory Disorders fungi Allergens medicine.disease Sensory Systems Allergic conjunctivitis Ophthalmology medicine.anatomical_structure Tears Immunology biology.protein Total serum IgE Antibody business |
Zdroj: | Graefe's Archive for Clinical and Experimental Ophthalmology |
ISSN: | 1435-702X 0721-832X |
Popis: | Background Recently, the number of patients with pollinosis, particularly Japanese cedar pollinosis, has markedly increased. We previously reported about local allergic conjunctivitis, which is a phenotype of allergic conjunctivitis (AC). AC cases are often sensitized by various antigens. This study aimed to investigate the relationship among total tear IgE (t-tIgE), specific serum IgE (s-sIgE), and total serum IgE (t-sIgE) levels in patients with pollen-induced AC. Methods In 2019, 1372 patients were clinically diagnosed with AC at the Yamana Eye Clinic using t-tIgE, t-sIgE, and s-sIgE tests against 39 allergens. Among the pollen-induced AC patients who underwent allergen testing, 99 tested positives for s-sIgE against pollen. The subjects comprised 33 (33.3%) male and 66 (66.7%) female individuals aged 9–86 years. Results The t-tIgE test was positive in 68 (68.7%) patients and negative in 31 (31.3%) patients. In the t-sIgE test, 45 (45.5%) patients had t-sIgE levels above the reference value of 170 IU/mL. The higher the total score of the positive class value of each pollen-specific IgE (pollen-sIgE) antibody, the higher the positive rate of t-tIgE (p Conclusions Pollen-induced AC is caused by pollen sensitization of the conjunctiva. Food-induced AC might be induced by the different pathological mechanism involved in pollen-induced AC. |
Databáze: | OpenAIRE |
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