Oxidative stress and disturbance in antioxidant balance in beta thalassemia major
| Autor: | N G Joshi, A.N. Suryakar, Rahul A Ghone, K. M. Kumbar, R. V. Katkam |
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| Jazyk: | angličtina |
| Rok vydání: | 2008 |
| Předmět: |
medicine.medical_specialty
Blood transfusion Antioxidant medicine.diagnostic_test Lipid peroxide biology business.industry medicine.medical_treatment Vitamin E Clinical Biochemistry medicine.disease_cause Article Pathogenesis Superoxide dismutase Endocrinology Total iron-binding capacity Internal medicine Immunology medicine biology.protein business Oxidative stress |
| Popis: | Repeated blood transfusion in beta thalassemia major patients may lead to peroxidative tissue injury by secondary iron overload. In the present study, 72 children with beta thalassemia major were included. Serum levels of total lipid peroxides, Iron, Total Iron Binding Capacity, Copper, Zinc, Vitamin E, plasma Total Antioxidant Capacity, activity of Erythrocyte Superoxide Dismutase, were measured. The findings were compared with 72 age matched healthy controls irrespective of sex. A significant increase in the levels of lipid peroxide and Iron (p0.05) was found in the patients when compared with controls. This suggest that oxidative stress and reduced antioxidant defense mechanism play an important role in pathogenesis of beta thalassemia major. |
| Databáze: | OpenAIRE |
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